Evidence map›Paper›PMID 39554133›Full record

ArticlebioRxiv : the preprint server for biology2024

Breast tumor microbiome regulates anti-tumor immunity and T cell-associated metabolites.

Chin-Chih Liu, Dennis Grencewicz, Karthik Chakravarthy, Lin Li, Ruth Liepold, Matthew Wolf, Naseer Sangwan, Alice Tzeng, Rebecca Hoyd, Sachin R Jhawar and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Chin-Chih LiuGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0001-6178-4521
Dennis GrencewiczThe Ohio State University College of Medicine, Columbus, OH 43201, USA.
Karthik ChakravarthyPelotonia Institute for Immuno-Oncology at The Ohio State University Comprehensive Cancer Center, 460 W12th Ave., BRT 480, Columbus, OH 43220, USA.
Lin LiCenter for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic, Cleveland, OH 44195, USA.
Ruth LiepoldGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Matthew WolfGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Naseer SangwanMicrobiome Composition and Analytics Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Alice TzengDepartment of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215, USA.
Rebecca HoydPelotonia Institute for Immuno-Oncology at The Ohio State University Comprehensive Cancer Center, 460 W12th Ave., BRT 480, Columbus, OH 43220, USA.
Sachin R JhawarDepartment of Radiation Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Stephen R GrobmyerCleveland Clinic Abu Dhabi, Oncology Institute, Abu Dhabi, United Arab Emirates.
Zahraa Al-HilliDepartment of General Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
Andrew P SciallisDepartment of Anatomic Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Daniel SpakowiczPelotonia Institute for Immuno-Oncology at The Ohio State University Comprehensive Cancer Center, 460 W12th Ave., BRT 480, Columbus, OH 43220, USA.ORCID 0000-0003-2314-6435
Ying NiCenter for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic, Cleveland, OH 44195, USA.
Charis EngGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
The Ohio State University Center for Clinical and Translational Science (UL1)UL1TR000090 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2012 to 2013
$7.9M
Cleveland Clinic integrative behavior-single cell proteomics workflowS10OD025207 · OD · CLEVELAND CLINIC LERNER COM-CWRU · PI DESILVA, TARA MARIA · 2019 to 2019
$745k
The microbiome in older adults with lung cancer: association of treatment regimens and diet with protective microbial profilesK01AG070310 · NIA · OHIO STATE UNIVERSITY · PI SPAKOWICZ, DANIEL J. · 2021 to 2025
$583k
NCATS NIH HHS UL1 TR000090NCI NIH HHS P30 CA016058NIA NIH HHS K01 AG070310NIH HHS S10 OD025207
6 · The paper itself

Abstract

Background: Breast cancer, the most common cancer type among women, was recently found to contain a specific tumor microbiome, but its impact on host biology remains unclear. CD8 Methods: We investigated the interplay among CD8 Results: In tumors from Cohort A, the relative abundance of Conclusions: We identified specific metabolites and microbial taxa associated with CD8

Indexed as

anti-tumor immunitybreast cancermetabolismmetabolomeMicrobiomeS. aureusStaphylococcusT cellstumor-infiltrating lymphocytestumor microenvironment

Identifiers

PMID39554133
PMCPMC11565759

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.