Evidence map›Paper›PMID 39554088›Full record

ArticlebioRxiv : the preprint server for biology2024

Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy.

Song-Yi Lee, Heegwang Roh, David Gonzalez-Perez, Mason R Mackey, Keun-Young Kim, Daniel Hoces, Colleen N McLaughlin, Stephen R Adams, Khanh Nguyen, David J Luginbuhl and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Song-Yi LeeDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Heegwang RohDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
David Gonzalez-PerezDepartment of Biocatalysis, Institute of Catalysis, ICP-CSIC, 28049, Madrid, Spain.
Mason R MackeyDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Keun-Young KimDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Daniel HocesDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Colleen N McLaughlinDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Stephen R AdamsDepartment of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.
Khanh NguyenBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
David J LuginbuhlDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Liqun LuoDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Namrata D UdeshiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Rogelio A Hernández-LópezDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Mark H EllismanDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Miguel AlcaldeDepartment of Biocatalysis, Institute of Catalysis, ICP-CSIC, 28049, Madrid, Spain.
Alice Y TingDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.

Funding

An Encyclopedia of the Adipose Tissue Secretome to Identify Mediators of Health and DiseaseRC2DK129961 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T, COHEN, PAUL · 2021 to 2025
$9.2M
RIGERR: Resources for Investigating Genetic and Epigenetic Regulation of Renal DiseaseRC2DK129964 · NIDDK · UNIVERSITY OF ARIZONA · PI MINGYU LIANG · 2022 to 2026
$4.9M
Cell surface protein dynamics in neural circuit assemblyK99DC021195 · NIDCD · STANFORD UNIVERSITY · PI MCLAUGHLIN, COLLEEN · 2024 to 2025
$257k
NIDCD NIH HHS K99 DC021195NIDCD NIH HHS L30 DC006982NIDDK NIH HHS RC2 DK129961NIDDK NIH HHS RC2 DK129964
6 · The paper itself

Abstract

Enzymes that oxidize aromatic substrates have shown utility in a range of cell-based technologies including live cell proximity labeling (PL) and electron microscopy (EM), but are associated with drawbacks such as the need for toxic H

Identifiers

PMID39554088
PMCPMC11565909

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.