Evidence map›Paper›PMID 39554077›Full record

ArticlebioRxiv : the preprint server for biology2024

The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome.

Paul H Kim, Joonyoung R Kim, Patrick J Heizer, Hyesoo Jung, Yiping Tu, Ashley Presnell, Julia Scheithauer, Rachel G Yu, Stephen G Young, Loren G Fong

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Paul H KimDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.
Joonyoung R KimDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.
Patrick J HeizerDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.
Hyesoo JungDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.
Yiping TuDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.
Ashley PresnellDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.
Julia ScheithauerDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.
Rachel G YuDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.
Stephen G YoungDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.ORCID 0000-0001-7270-3176
Loren G FongDepartment of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.ORCID 0000-0002-4465-5290

Funding

Understanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2019 to 2023
$11.7M
Investigating Mechanisms for Lipid Transport in Health and DiseaseR35HL139725 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2018 to 2024
$6.1M
Solving longstanding mysteries in plasma triglyceride metabolismR01HL171737 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNE BEIGNEUX, Loren Gi Fong · 2024 to 2026
$1.9M
NHLBI NIH HHS P01 HL146358NHLBI NIH HHS R01 HL171737NHLBI NIH HHS R35 HL139725
6 · The paper itself

Abstract

Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disorder characterized by multiple aging-like phenotypes, including disease in large arteries. HGPS is caused by an internally truncated prelamin A (progerin) that cannot undergo the ZMPSTE24-mediated processing step that converts farnesyl-prelamin A to mature lamin A; consequently, progerin retains a carboxyl-terminal farnesyl lipid anchor. In cultured cells, progerin and full-length farnesyl-prelamin A (produced in

Identifiers

PMID39554077
PMCPMC11565845

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.