Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
25 authors.
Larissa JankDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0008-7316-8054
Saumitra S SinghDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4083-6681
Judy LeeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Asmita DhukhwaDepartment of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0006-2769-8308
Fatemeh SiavoshiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Deepika JoshiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Veronica MinneyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kanak GuptaDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-9636-2350
Sudeep GhimireDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-7769-7764
Pragney DemeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9117-891X
Vinicius A SchoepsDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-8875-0567
Karthik SomanDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID 0000-0002-3490-9306
Dimitrios LadakisDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5764-2114
Matthew SmithDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6614-569X
Kamil BorkowskiWest Coast Metabolomics Center, University of California Davis, Davis, CA, USA.ORCID 0000-0003-3637-3450
John NewmanObesity and Metabolism Research, Agriculture Research Service, United States Department of Agriculture, Davis, CA, USA.ORCID 0000-0001-9632-6571
Sergio E BaranziniDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID 0000-0003-0067-194X
Emmanuelle L WaubantDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-5188-0157
Kathryn C FitzgeraldDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3137-0322
Ashutosh MangalamDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-9926-2531
Norman HaugheyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5194-4122
Michael KornbergDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2588-7325
Xitiz ChamlingDepartment of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6401-7715
Peter A CalabresiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7776-6472
Pavan BhargavaDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7947-9418
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
The Role of KV1.3 in Effector T cellsR01NS041435 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI CALABRESI, PETER A · 2000 to 2025
$5.8M
INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007260 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WU, LI · 1986 to 2023
$5.7M
Metabolic correlates of disease activity and disability progression in pediatric MSR01NS117541 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2021 to 2023
$1.1M
Developing Remyelination Strategies for Demyelinating Optic Neuropathies Using Human Pluripotent Stem CellsR00EY029011 · NEI · JOHNS HOPKINS UNIVERSITY · PI CHAMLING, XITIZ · 2022 to 2024
$731k
Understanding the role of aromatic amino acid derived metabolic toxins in neuroinflammationR21NS123141 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BHARGAVA, PAVAN · 2022 to 2023
In multiple sclerosis (MS) the circulating metabolome is dysregulated, with indole lactate (ILA) being one of the most significantly reduced metabolites. We demonstrate that oral supplementation of ILA impacts key MS disease processes in two preclinical models. ILA reduces neuroinflammation by dampening immune cell activation as well as infiltration; and promotes remyelination and
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation. · full record | OpenQuestion