Evidence map›Paper›PMID 39554061›Full record

ArticlebioRxiv : the preprint server for biology2025

NSAID-mediated cyclooxygenase inhibition disrupts ectodermal derivative formation in axolotl embryos.

Emma J Marshall, Raneesh Ramarapu, Tess A Leathers, Nikolas Morrison-Welch, Kathryn Sandberg, Maxim Kawashima, Crystal D Rogers

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Emma J MarshallDepartment of Anatomy, Physiology, and Cell Biology, University of California, Davis, Davis, CA, USA.
Raneesh RamarapuDepartment of Anatomy, Physiology, and Cell Biology, University of California, Davis, Davis, CA, USA.
Tess A LeathersDepartment of Anatomy, Physiology, and Cell Biology, University of California, Davis, Davis, CA, USA.
Nikolas Morrison-WelchDepartment of Biology, California State University, Northridge, Northridge, CA, USA.
Kathryn SandbergDepartment of Anatomy, Physiology, and Cell Biology, University of California, Davis, Davis, CA, USA.
Maxim KawashimaDepartment of Anatomy, Physiology, and Cell Biology, University of California, Davis, Davis, CA, USA.
Crystal D RogersDepartment of Anatomy, Physiology, and Cell Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-9549-1089

Funding

Vision Science Training Program: Cornea to CortexT32EY015387 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI MARIE E BURNS · 2003 to 2026
$4.8M
The UC Davis enhanced Molecular, Cellular, and Developmental Biology Training ProgramT32GM153586 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Frederic Louis Chedin, ELVA D DIAZ · 2024 to 2026
$2.3M
Mechanisms of microtubule-mediated cranial neural crest EMT and differentiationR03DE032047 · NIDCR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ROGERS, CRYSTAL D · 2022 to 2023
$300k
NEI NIH HHS T32 EY015387NIDCR NIH HHS R03 DE032047NIGMS NIH HHS T32 GM153586
6 · The paper itself

Abstract

Embryonic exposures to non-stseroidal anti-inflammatory drugs (NSAIDs) have been linked to preterm birth, neural tube closure defects, abnormal enteric innervation, and craniofacial malformations, potentially due to disrupted neural tube or neural crest (NC) cell development. Naproxen (NPX), a common non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, exerts its effects through non-selective cyclooxygenase (COX) inhibition. Our lab has identified that the cyclooxygenase (COX-1 and COX-2) isoenzymes are expressed during the early stages of vertebrate embryonic development, and that global inhibition of COX-1 and COX-2 function disrupts NC cell migration and differentiation in

Indexed as

axolotlCOX-1COX-2cyclooxygenasenaproxenneural crestNSAID

Identifiers

PMID39554061
PMCPMC11565853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.