Evidence map›Paper›PMID 39554054›Full record

ArticlebioRxiv : the preprint server for biology2025

Pervasive fitness trade-offs revealed by rapid adaptation to shifting population densities in large experimental populations of

M C Bitter, S Greenblum, S Rajpurohit, A O Bergland, J A Hemker, Egor Lappo, N J Betancourt, S Tilk, S Berardi, H Oken and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

M C BitterDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7607-2375
S GreenblumDepartment of Biology, Stanford University, Stanford, CA, USA.
S RajpurohitDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9149-391X
A O BerglandDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7145-7575
J A HemkerDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7598-8741
Egor LappoDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0847-4070
N J BetancourtDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
S TilkDepartment of Biology, Stanford University, Stanford, CA, USA.
S BerardiDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0009-0627-8007
H OkenDepartment of Biology, Stanford University, Stanford, CA, USA.
P SchmidtDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8076-6705
D A PetrovDepartment of Biology, Stanford University, Stanford, CA, USA.

Funding

Genomics of rapid adaptation in the lab and in the wildR35GM118165 · NIGMS · STANFORD UNIVERSITY · PI Dmitri Petrov · 2016 to 2026
$8.3M
Genomics of rapid adaptation on seasonal timescales in D. melanogasterR01GM100366 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SCHMIDT, PAUL · 2012 to 2019
$3.3M
Rapid evolution of pigmentation in D. melanogaster: from cis regulation to phenotypeR01GM137430 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MCINTYRE, LAUREN M., SCHMIDT, PAUL · 2021 to 2024
$2.2M
NIGMS NIH HHS R01 GM100366NIGMS NIH HHS R01 GM137430NIGMS NIH HHS R35 GM118165
6 · The paper itself

Abstract

Trade-offs are an inherent feature of organismal biology that are expected play a fundamental role in the evolution of natural populations. Efforts to quantify trade-offs are largely confined to phenotypic measurements and the identification of negative genetic-correlations among fitness-relevant traits. Here, we use time-series genomic data collected during experimental evolution in large, genetically diverse populations of

Indexed as

adaptationDrosophila melanogastereco-evolutionary feedbacksexperimental evolutionfluctuating selectiongenomicspopulation density fluctuationstrade-offs

Identifiers

PMID39554054
PMCPMC11565731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.