Evidence map›Paper›PMID 39554051›Full record

ArticlebioRxiv : the preprint server for biology2024

The CYK-4 GAP domain regulates cortical targeting of centralspindlin to promote contractile ring assembly and facilitate ring dissolution.

Aleesa J Schlientz, Kian-Yong Lee, J Sebastián Gómez-Cavazos, Pablo Lara-González, Arshad Desai, Karen Oegema

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aleesa J SchlientzDepartment of Cell & Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0002-7281-8851
Kian-Yong LeeDepartment of Cellular & Molecular Medicine, University of California San Diego, La Jolla, California 92093, USA.
J Sebastián Gómez-CavazosDepartment of Cell & Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA.
Pablo Lara-GonzálezDepartment of Cellular & Molecular Medicine, University of California San Diego, La Jolla, California 92093, USA.
Arshad DesaiDepartment of Cell & Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0002-5410-1830
Karen OegemaDepartment of Cell & Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0001-8515-7514

Funding

Mechanisms of CytokinesisR01GM147265 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OEGEMA, KAREN F · 2022 to 2025
$1.8M
Developmental regulation of the cell cycle machineryR35GM150786 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pablo Andres Lara-Gonzalez · 2023 to 2026
$1.5M
Dissecting the role of Aurora A kinase in patterning the cell cortex during cytokinesis.F32GM145068 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHLIENTZ, ALEESA · 2022 to 2023
$137k
NIGMS NIH HHS F32 GM145068NIGMS NIH HHS R01 GM147265NIGMS NIH HHS R35 GM150786
6 · The paper itself

Abstract

During cytokinesis, an equatorial contractile ring partitions the cell contents. Contractile ring assembly requires an equatorial zone of active GTP-bound RhoA generated by the guanine nucleotide exchange factor ECT2

Indexed as

Cell DivisioncentralspindlinCYK-4CYK4CytokinesisECT-2ECT2GAP domainRhoA

Identifiers

PMID39554051
PMCPMC11565784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.