Evidence map›Paper›PMID 39554036›Full record

ArticlebioRxiv : the preprint server for biology2024

Mechanistic insights into structure-based design of a Lyme disease subunit vaccine.

Kalvis Brangulis, Jill Malfetano, Ashley L Marcinkiewicz, Alan Wang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Maria-Elena Bottazzi and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Kalvis BrangulisLatvian Biomedical Research and Study Centre, Riga, Latvia.
Jill MalfetanoDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Ashley L MarcinkiewiczDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Alan WangDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Yi-Lin ChenDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Jungsoon LeeDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Zhuyun LiuDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Xiuli YangDepartment of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, United States.
Ulrich StrychDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Maria-Elena BottazziDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Utpal PalDepartment of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, United States.
Ching-Lin HsiehDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA.
Wen-Hsiang ChenDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Yi-Pin LinDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.ORCID 0000-0002-5240-2031

Funding

Multivalent Tick-Microbe targeted Lyme disease vaccinesR01AI154542 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL, SCHNELL, MATTHIAS JOHANNES · 2020 to 2025
$3.5M
Immunomodulatory mechanisms of wild bird reservoir hosts that facilitate persistence of Lyme disease bacteriaR01AI181746 · NIAID · TUFTS UNIVERSITY BOSTON · PI Yi-Pin Lin · 2024 to 2026
$2.5M
FH-Fc as a Pre-Exposure Prophylactic for Tickborne DiseaseR44AI152954 · NIAID · PLANET BIOTECHNOLOGY, INC. · PI LIN, YI-PIN, WYCOFF, KEITH · 2022 to 2023
$2.0M
Identification of the mechanism of protection against a B. burgdorferi protein CspZ for the prevention of Lyme diseaseR21AI144891 · NIAID · WADSWORTH CENTER · PI BOTTAZZI, MARIA ELENA, LIN, YI-PIN · 2020 to 2021
$441k
NIAID NIH HHS R01 AI154542NIAID NIH HHS R01 AI181746NIAID NIH HHS R21 AI144891NIAID NIH HHS R44 AI152954
6 · The paper itself

Abstract

The quality of protective immunity plays a critical role in modulating vaccine efficacy, with native antigens often not able to trigger sufficiently strong immune responses for pathogen killing. This warrants creation of structure-based vaccine design, leveraging high-resolution antigen structures for mutagenesis to improve protein stability and efficient immunization strategies. Here, we investigated the mechanisms underlying structure-based vaccine design using CspZ-YA, a vaccine antigen from

Indexed as

BorreliaCspZLyme diseaseVaccine

Identifiers

PMID39554036
PMCPMC11565809

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.