ArticlebioRxiv : the preprint server for biology2024
Dynamic imbalances in cell-type specific striatal ensemble activity during visually guided locomotion.
Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
Locomotion is continuously regulated by an animal's position within an environment relative to goals. Direct and indirect pathway striatal output neurons (dSPNs and iSPNs) influence locomotion, but how their activity is naturally coordinated by changing environments is unknown. We found, in head-fixed mice, that the relative balance of dSPN and iSPN activity was dynamically modulated with respect to position within a visually-guided locomotor trajectory to retrieve reward. Imbalances were present within ensembles of position-tuned SPNs which were sensitive to the visual environment. Our results suggest a model in which competitive imbalances in striatal output are created by learned associations with sensory input to shape context dependent locomotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.