Evidence map›Paper›PMID 39554025›Full record

ArticlebioRxiv : the preprint server for biology2024

Endothelial cell stiffness and type drive the formation of biomechanically-induced transcellular pores.

Seyed Mohammad Siadat, Haiyan Li, Brigid A Millette, Babak N Safa, Cydney A Wong, M Reza Bahrani Fard, Sietse T Braakman, Ian Tay, Jacques A Bertrand, A Thomas Read and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Seyed Mohammad SiadatWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.ORCID 0000-0002-5063-0305
Haiyan LiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
Brigid A MilletteWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
Babak N SafaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
Cydney A WongWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
M Reza Bahrani FardWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
Sietse T BraakmanDepartment of Bioengineering, Imperial College London, London, London, United Kingdom.
Ian TayDepartment of Bioengineering, Imperial College London, London, London, United Kingdom.
Jacques A BertrandDepartment of Bioengineering, Imperial College London, London, London, United Kingdom.
A Thomas ReadWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
Lisa A SchildmeyerWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
Kristin M PerkumasDepartment of Ophthalmology, Duke Eye Center, Duke University, Durham, NC, USA.
W Daniel StamerDepartment of Ophthalmology, Duke Eye Center, Duke University, Durham, NC, USA.
Darryl R OverbyDepartment of Bioengineering, Imperial College London, London, London, United Kingdom.
C Ross EthierWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.ORCID 0000-0001-6110-3052

Funding

eNOS-Dependent Mechanoregulation of Intraocular PressureR01EY022359 · NEI · DUKE UNIVERSITY · PI STAMER, W DANIEL · 2012 to 2025
$5.6M
Caveolae-Based Mechanosensors for Conventional Outflow RegulationR01EY028608 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MICHAEL H ELLIOTT, W Daniel Stamer · 2018 to 2026
$3.8M
Transcriptional and Biomechanical Analysis of Segmental Outflow in GlaucomaR01EY031710 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ETHIER, C ROSS, GUPTA, DIVAKAR · 2020 to 2023
$2.4M
T32 CTEng (Cellular and Tissue Engineering) Training ProgramT32GM145735 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Edward A. Botchwey, Andres J Garcia · 2022 to 2026
$2.3M
Schlemm’s canal on a chip: A platform for screening a novel class of glaucoma medicationsR21EY033142 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ETHIER, C ROSS · 2021 to 2022
$405k
The role of iris biomechanics and sex differences in primary angle-closure glaucomaK99EY035360 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI NAGHIZADEH SAFA, BABAK · 2023 to 2024
$224k
NEI NIH HHS K99 EY035360NEI NIH HHS R01 EY022359NEI NIH HHS R01 EY028608NEI NIH HHS R01 EY031710NEI NIH HHS R21 EY033142NIGMS NIH HHS T32 GM145735
6 · The paper itself

Abstract

Formation of transcellular pores facilitates the transport of materials across endothelial barriers. In Schlemm's canal (SC) endothelium, impaired pore formation is associated with glaucoma. However, our understanding of the cellular processes responsible for pore formation is limited by lack of

Identifiers

PMID39554025
PMCPMC11565842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.