Evidence map›Paper›PMID 39553992›Full record

ArticlebioRxiv : the preprint server for biology2024

Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels.

Yogesh Hooda, Andrija Sente, Ryan M Judy, Luka Smalinskaitė, Sew-Yeu Peak-Chew, Katerina Naydenova, Tomas Malinauskas, Steven W Hardwick, Dimitri Y Chirgadze, A Radu Aricescu and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yogesh HoodaMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.ORCID 0000-0002-7181-9254
Andrija SenteMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.ORCID 0000-0001-5407-9138
Ryan M JudyMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.ORCID 0000-0001-6210-0128
Luka SmalinskaitėMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.ORCID 0000-0001-6023-8262
Sew-Yeu Peak-ChewMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.
Katerina NaydenovaMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.ORCID 0000-0001-5533-5930
Tomas MalinauskasDivision of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.ORCID 0000-0002-4847-5529
Steven W HardwickDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom.ORCID 0000-0001-9246-1864
Dimitri Y ChirgadzeDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom.ORCID 0000-0001-9942-0993
A Radu AricescuMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.ORCID 0000-0003-3783-1388
Ramanujan S HegdeMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.ORCID 0000-0001-8338-852X

Funding

Molecular Pharmacology of the Synaptic and Extrasynaptic GABA(A) ReceptorsR01GM135550 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 2020 to 2023
$2.8M
NIGMS NIH HHS R01 GM135550Wellcome Trust
6 · The paper itself

Abstract

Pentameric ligand-gated ion channels (pLGICs) are cell surface receptors of crucial importance for animal physiology

Identifiers

PMID39553992
PMCPMC11565801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.