Evidence map›Paper›PMID 39553973›Full record

ArticlebioRxiv : the preprint server for biology2025

Conserved transcription factors coordinate synaptic gene expression through repression.

James A Kentro, Gunjan Singh, Tuan M Pham, Justin Currie, Saniya Khullar, Audrey T Medeiros, Maria Tsiarli, Erica Larschan, Kate M O'Connor-Giles

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James A KentroDepartment of Molecular Biology, Cell Biology, & Biochemistry, Brown University, Providence, RI, USA.ORCID 0000-0002-1315-6149
Gunjan SinghDepartment of Molecular Biology, Cell Biology, & Biochemistry, Brown University, Providence, RI, USA.ORCID 0000-0002-4458-180X
Tuan M PhamDepartment of Molecular Biology, Cell Biology, & Biochemistry, Brown University, Providence, RI, USA.ORCID 0009-0005-8622-1203
Justin CurrieDepartment of Molecular Biology, Cell Biology, & Biochemistry, Brown University, Providence, RI, USA.ORCID 0009-0004-5846-9853
Saniya KhullarWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-4166-874X
Audrey T MedeirosDepartment of Neuroscience, Brown University, Providence, RI, USA.ORCID 0000-0002-5562-4772
Maria TsiarliDepartment of Molecular Biology, Cell Biology, & Biochemistry, Brown University, Providence, RI, USA.
Erica LarschanDepartment of Molecular Biology, Cell Biology, & Biochemistry, Brown University, Providence, RI, USA.ORCID 0000-0003-2484-4921
Kate M O'Connor-GilesDepartment of Neuroscience, Brown University, Providence, RI, USA.ORCID 0000-0002-2259-8408

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Interdisciplinary Predoctoral Neuroscience Training Program in the Neuroscience Graduate Program.T32MH020068 · NIMH · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE, SHEINBERG, DAVID L · 1999 to 2025
$7.6M
Predoctoral Training in Molecular, Cellular, and Biochemical SciencesT32GM136566 · NIGMS · BROWN UNIVERSITY · PI Mark Aikens Johnson, Erica Nicole Larschan · 2020 to 2026
$3.1M
Coregulation of genes by pioneer transcription factors and noncoding RNAsR35GM153389 · NIGMS · BROWN UNIVERSITY · PI Erica Nicole Larschan · 2024 to 2026
$1.5M
Identification and characterization of chromatin regulators of coordinated synaptic gene expressionR21NS125864 · NINDS · BROWN UNIVERSITY · PI LARSCHAN, ERICA NICOLE, O'CONNOR-GILES, KATHALEEN M · 2021 to 2021
$429k
NIGMS NIH HHS R35 GM153389NIGMS NIH HHS T32 GM136566NIH HHS P40 OD018537NIMH NIH HHS T32 MH020068NINDS NIH HHS R21 NS125864
6 · The paper itself

Abstract

Chemical synapses are the primary sites of communication in the nervous system. Synapse formation is a complex process involving hundreds of proteins that must be expressed in two cells at the same time. We find that synaptic genes are broadly and specifically coordinated at the level of transcription across developing nervous systems. How this spatiotemporal coordination is achieved remains an open question. Through genomic and functional studies in

Identifiers

PMID39553973
PMCPMC11565943

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.