Evidence map›Paper›PMID 39553933›Full record

ArticlebioRxiv : the preprint server for biology2024

DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge.

Victoria Gnazzo, Hanaa Saleh, Ítalo Castro, Adrianus C M Boon, Amelia K Pinto, James D Brien, Carolina B López

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Victoria GnazzoDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO.
Hanaa SalehDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO.
Ítalo CastroDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO.
Adrianus C M BoonDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO.
Amelia K PintoDepartment of Microbiology, Immunology & Molecular Genetics, University of Kentucky, Lexington KY.
James D BrienDepartment of Microbiology, Immunology & Molecular Genetics, University of Kentucky, Lexington KY.
Carolina B LópezDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO.ORCID 0000-0002-7669-6572

Funding

SARS-CoV-2 correlates of protection in a Latino-origin populationU01CA260541 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BRIEN, JAMES D, LOPEZ, MARCOS · 2020 to 2024
$3.4M
Mechanisms of DDO AdjuvancyR01AI134862 · NIAID · WASHINGTON UNIVERSITY · PI LOPEZ, CAROLINA B. · 2018 to 2022
$2.4M
Harnessing ZBP1-driven cell death to improve influenza vaccine efficacyR56AI150965 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH, LANGLOIS, RYAN · 2021 to 2021
$848k
NCI NIH HHS U01 CA260541NIAID NIH HHS R01 AI134862
6 · The paper itself

Abstract

A challenge in viral vaccine development is to produce vaccines that generate both neutralizing antibodies to prevent infection and cytotoxic CD8

Identifiers

PMID39553933
PMCPMC11565765

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.