ArticleBiomedical optics express2024
Development of an ultrafast laser system based on a Yb-doped fiber and a Yb:YAG thin-rod for the preclinical study of pigmented lesions treatment using a Hartley guinea pig.
Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this research, we developed an ultrafast laser system based on a Yb-doped fiber oscillator and Yb:YAG thin-rod amplifier to investigate the efficacy of the laser for the treatment of pigmented lesions. The developed laser exhibited an output power of 22.7 W, center wavelength of 1030 nm, repetition rate of 495 kHz, pulse energy of 45.9 µJ, and pulse duration of 1.56 ps, respectively. For a compact and stable chirped pulse amplification system, a chirped fiber Bragg grating (CFBG) stretcher and a chirped volume Bragg grating (CVBG) compressor, both with fixed dispersion, were used. The dispersion of the total laser systems was precisely compensated by adjusting the length of the passive fiber and utilizing the self-phase modulation effect of the fiber amplifier. The developed ultrafast laser system was then applied in preclinical studies for the treatment of pigmented lesions in a guinea pig model. Three colored squares, each measuring approximately 15 × 15 mm, were treated by scanning a focused beam with varying laser fluences ranging from 0.5 to 2 J/cm
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