Evidence map›Paper›PMID 39553865›Full record

ArticleBiomedical optics express2024

Improving cone identification using merged non-confocal quadrant-detection adaptive optics scanning light ophthalmoscope images.

Toco Y P Chui, Justin V Migacz, Luis Muncharaz Duran, Affan Haq, Oscar Otero-Marquez, Alfredo Dubra, Richard B Rosen

Abstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Toco Y P ChuiDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.ORCID https://orcid.org/0000-0003-2060-3848
Justin V MigaczDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.
Luis Muncharaz DuranDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.
Affan HaqDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.
Oscar Otero-MarquezDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.
Alfredo DubraDepartment of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA.ORCID https://orcid.org/0000-0002-6506-9020
Richard B RosenDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
SCD REVIVE - Retina to Evaluate Vaso occlusion In the Vasculature of the EyeR01HL159116 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Yuen Ping Toco Chui, Jeffrey Avins Glassberg · 2022 to 2026
$4.0M
Characterization of vascular responses to intravitreal anti-VEGF injections in diabetic retinopathyR01EY027301 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Yuen Ping Toco Chui · 2017 to 2026
$4.0M
Increasing the isoplanatic patch in adaptive optics ophthalmoscopyR01EY032147 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2021 to 2025
$2.4M
Improving rigor and reproducibility in adaptive optics ophthalmoscopyR01EY031360 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2020 to 2023
$2.3M
Low Latency Eye-Motion CompensationR01EY032669 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2021 to 2024
$1.8M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY027301NEI NIH HHS R01 EY031360NEI NIH HHS R01 EY032147NEI NIH HHS R01 EY032669NHLBI NIH HHS R01 HL159116
6 · The paper itself

Abstract

Cone photoreceptor inner segments visualized in non-confocal split-detection adaptive optics scanning light ophthalmoscope (AOSLO) images appear as obliquely illuminated domes with bright and dark opposing regions. Previously, the pairing of these bright and dark regions for automated photoreceptor identification has necessitated complex algorithms. Here we demonstrate how the merging of split-detection images captured with a non-confocal quadrant light detection scheme allows automated cone identification using simple, open-source image processing tools, while also improving accuracy in both normal and pathologic retinas.

Identifiers

PMID39553865
PMCPMC11563324

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.