Evidence map›Paper›PMID 39553429›Full record

ArticleBioengineering & translational medicine2024

Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation.

Molly K Grun, Praveen Honhar, Yazhe Wang, Samantha Rossano, Minsoo Khang, Hee Won Suh, Krista Fowles, Harvey J Kliman, Alessandra Cavaliere, Richard E Carson and 2 more

Abstract read
In one paragraph

Article in Bioengineering & translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Molly K GrunDepartment of Chemical & Environmental Engineering Yale University New Haven Connecticut USA.
Praveen HonharDepartment of Biomedical Engineering Yale University New Haven Connecticut USA.ORCID https://orcid.org/0000-0001-9073-6270
Yazhe WangDepartment of Biomedical Engineering Yale University New Haven Connecticut USA.
Samantha RossanoDepartment of Biomedical Engineering Yale University New Haven Connecticut USA.
Minsoo KhangDepartment of Biomedical Engineering Yale University New Haven Connecticut USA.
Hee Won SuhDepartment of Biomedical Engineering Yale University New Haven Connecticut USA.
Krista FowlesDepartment of Radiology & Biomedical Imaging Yale School of Medicine New Haven Connecticut USA.
Harvey J KlimanDepartment of Obstetrics, Gynecology & Reproductive Sciences Yale School of Medicine New Haven Connecticut USA.
Alessandra CavaliereDepartment of Radiology & Biomedical Imaging Yale School of Medicine New Haven Connecticut USA.
Richard E CarsonDepartment of Biomedical Engineering Yale University New Haven Connecticut USA.
Bernadette Marquez-NostraDepartment of Radiology, Division of Advanced Medical Imaging Research University of Alabama at Birmingham Birmingham Alabama USA.
W Mark SaltzmanDepartment of Chemical & Environmental Engineering Yale University New Haven Connecticut USA.ORCID https://orcid.org/0000-0002-2163-549X

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Molecular and Cellular Transport in MucusR01EB000487 · NIBIB · YALE UNIVERSITY · PI IWASAKI, AKIKO, SALTZMAN, W. MARK · 2002 to 2019
$5.0M
State-of-the-Art PET/CT InstrumentationS10RR029245 · NCRR · YALE UNIVERSITY · PI CARSON, RICHARD E. · 2010 to 2010
$2.3M
NCATS NIH HHS UL1 TR001863NCRR NIH HHS S10 RR029245NIBIB NIH HHS R01 EB000487
6 · The paper itself

Abstract

Long-lasting vaginal dosage forms could improve the therapeutic efficacy of vaginal microbicides, but achieving long-term delivery to the vaginal canal has been a significant challenge. To advance understanding of vaginal dosage retention and biodistribution, we describe a method of noninvasive imaging with

Indexed as

biocompatiblebiodegradablemicrobicidenanoparticlevaginal drug delivery

Identifiers

PMID39553429
PMCPMC11561825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.