Evidence map›Paper›PMID 39553383›Full record

ArticlePhotoacoustics2024

Quantitative volumetric photoacoustic assessment of vasoconstriction by topical corticosteroid application in mice skin.

Donggyu Kim, Joongho Ahn, Donghyun Kim, Jin Young Kim, Seungah Yoo, Ji Hyun Lee, Priyanka Ghosh, Markham C Luke, Chulhong Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photoacoustics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  9. A Hybrid Diffusion Model Enhances Multiparametric 3D Photoacoustic Computed Tomography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  10. Article
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  17. Photoacoustics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Donggyu KimDepartment of Convergence IT Engineering, Electrical Engineering, Mechanical Engineering, Medical Science and Engineering, Graduate School of Artificial Intelligence, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Joongho AhnDepartment of Convergence IT Engineering, Electrical Engineering, Mechanical Engineering, Medical Science and Engineering, Graduate School of Artificial Intelligence, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Donghyun KimDepartment of Convergence IT Engineering, Electrical Engineering, Mechanical Engineering, Medical Science and Engineering, Graduate School of Artificial Intelligence, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Jin Young KimDepartment of Convergence IT Engineering, Electrical Engineering, Mechanical Engineering, Medical Science and Engineering, Graduate School of Artificial Intelligence, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Seungah YooDepartment of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Ji Hyun LeeDepartment of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Priyanka GhoshDivision of Therapeutic Performance I, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Markham C LukeDivision of Therapeutic Performance I, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Chulhong KimDepartment of Convergence IT Engineering, Electrical Engineering, Mechanical Engineering, Medical Science and Engineering, Graduate School of Artificial Intelligence, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Topical corticosteroids manage inflammatory skin conditions via their action on the immune system. An effect of application of corticosteroids to the skin is skin blanching caused by peripheral vasoconstriction. This has been used to characterize, in some cases relative potency and also as a way to compare skin penetration. Chromameters have been used to assess skin blanching-the outcome of vasoconstriction caused by topical corticosteroids-but do not directly measure vasoconstriction. Here, we demonstrate quantitative volumetric photoacoustic microscopy (PAM) as a tool for directly assessing the vasoconstriction followed by topical corticosteroid application, noninvasively visualizing skin vasculature without any exogeneous contrast agent. We photoacoustically differentiated the vasoconstrictive ability of four topical corticosteroids in small animals through multiparametric analyses, offering detailed 3D insights into vasoconstrictive mechanisms across different skin depths. Our findings highlight the potential of PAM as a noninvasive tool for measurement of comparative vasoconstriction with potential for clinical, pharmaceutical, and bioequivalence applications.

Indexed as

Photoacoustic microscopyTopical corticosteroidVasoconstriction

Identifiers

PMID39553383
PMCPMC11563941

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.