Evidence map›Paper›PMID 39553358›Full record

ArticleMaedica2024

Advancing Diagnostic Techniques for Implant-Related Infections: the Synergistic Effect of Sonication and Dithiothreitol.

Matthaios Bakalakos, Margarita-Michaela Ampadiotaki, Christos Vlachos, Antonios Stylianakis, Nikolaos Sipsas, Spiros Pneumaticos, John Vlamis

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Maedica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthaios Bakalakos3rd Orthopaedic Department, National and Kapodistrian University of Athens, KAT General Hospital, Athens, Greece.
Margarita-Michaela Ampadiotaki2nd Orthopaedic Department, KAT General Hospital, Athens, Greece.
Christos Vlachos3rd Orthopaedic Department, National and Kapodistrian University of Athens, KAT General Hospital, Athens, Greece.
Antonios StylianakisMicrobiology Department, KAT General Hospital, 14561 Athens, Greece.
Nikolaos SipsasInfectious Diseases, National and Kapodistrian University of Athens, Athens, Greece.
Spiros Pneumaticos3rd Orthopaedic Department, National and Kapodistrian University of Athens, KAT General Hospital, Athens, Greece.
John Vlamis3rd Orthopaedic Department, National and Kapodistrian University of Athens, KAT General Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeImplant-related infections represent a significant complication contributing to increased morbidity and mortality. Determining the microbial agent causing the infection is crucial for successful treatment. Despite the incidence of periprosthetic joint infections (PJIs) rising over time, no diagnostic test with 100% sensitivity is available to identify these infections accurately. The present study aims to determine whether combining sonication with Dithiothreitol (DTT) enhances the accuracy and sensitivity in diagnosing implant-related infections.

methodsSpecifically, the present study included 30 patients, who underwent implant removal due to suspicion of infection. Implants were divided into two segments: one was processed using the sonication method and the other one by combining DTT and sonication.

resultsThe mean +/-SD was 81.17 +/- 67.53 CFU/mL for the sonication group and 109.7 +/-62.78 CFU/mL for the combination group.

conclusionThe results of our study indicate that the combination of DTT and sonication increases the colony count by about 28.53 CFU/mL, which enhances the possibility of detecting orthopaedic implant associated infections.

Identifiers

PMID39553358
PMCPMC11565132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.