Evidence map›Paper›PMID 39553251›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Hippocampal volumes in UK Biobank are associated with

Ariya Chaloemtoem, Vera Thornton, Yoonhoo Chang, Andrey P Anokhin, Michaël E Belloy, Janine Bijsterbosch, Brian A Gordon, Sarah M Hartz, Laura J Bierut

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
  5. Hippocampal volumes in UK Biobank are associated withAlzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ariya ChaloemtoemDepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USA.ORCID https://orcid.org/0000-0003-0188-2431
Vera ThorntonDepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USA.
Yoonhoo ChangDepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USA.
Andrey P AnokhinDepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USA.
Michaël E BelloyNeuroGenomics and Informatics Center Washington University School of Medicine St. Louis Missouri USA.
Janine BijsterboschDepartment of Radiology Washington University School of Medicine St. Louis Missouri USA.
Brian A GordonNeuroGenomics and Informatics Center Washington University School of Medicine St. Louis Missouri USA.
Sarah M HartzDepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USA.
Laura J BierutDepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USA.ORCID https://orcid.org/0000-0002-9952-4810

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JESSICA E SALVATORE · 1989 to 2026
$162.7M
Imaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
Longitudinal multicenter head-to-head harmonization of tau PET tracersR01AG073267 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAKER, SUZANNE L, PASCOAL, THARICK · 2021 to 2025
$41.1M
Washington University Institute of Clinical and Translational Sciences (TL1)TL1TR002344 · NCATS · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2017 to 2026
$8.5M
Leveraging Heterogeneity in Autosomal Dominant AD to Elucidate Pathophysiology and Improve AD BiomarkersRF1AG079569 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHHATWAL, JASMEER P, LIU, LEI · 2022 to 2022
$4.4M
Neural and motivational mechanisms of age-related change in emotion regulation: Administrative SupplementR01AG070139 · NIA · WASHINGTON UNIVERSITY · PI ENGLISH, TAMMY, THOMPSON, RENEE J · 2021 to 2025
$4.3M
Returning Research Results that Indicate Risk of Alzheimer Disease to Healthy Participants in Longitudinal StudiesR01AG065234 · NIA · WASHINGTON UNIVERSITY · PI HARTZ, SARAH, MOZERSKY, JESSICA · 2020 to 2024
$3.8M
Multi 'Omics Integration and Neurobiological Signatures of Alcohol Use DisorderR01AA027049 · NIAAA · RESEARCH TRIANGLE INSTITUTE · PI BIERUT, LAURA J., HANCOCK, DANA B · 2019 to 2023
$3.0M
Neurobehavioral consequences of Mild Traumatic Brain Injury and addiction risk: a cotwin-control studyR01DA058114 · NIDA · WASHINGTON UNIVERSITY · PI Andrey P. Anokhin · 2023 to 2026
$2.8M
CHILDHOOD SEXUAL ABUSE AND PROBLEM DRINKING IN WOMEN: NEUROBEHAVIORAL MECHANISMSR01AA025646 · NIAAA · WASHINGTON UNIVERSITY · PI ANOKHIN, ANDREY P. · 2018 to 2022
$2.7M
The role of late life depression in cognitive decline and Alzheimer's Disease riskR01MH128286 · NIMH · WASHINGTON UNIVERSITY · PI Janine Diane Bijsterbosch · 2022 to 2026
$2.7M
NCATS NIH HHS TL1 TR002344NIAAA NIH HHS R01 AA025646NIAAA NIH HHS R01 AA027049NIAAA NIH HHS R01 AA029308NIAAA NIH HHS U10 AA008401NIA NIH HHS P01 AG026276NIA NIH HHS R00 AG075238NIA NIH HHS R01 AG065234NIA NIH HHS R01 AG070139NIA NIH HHS R01 AG073267NIA NIH HHS RF1 AG073424NIA NIH HHS RF1 AG079569NIA NIH HHS RF1 AG082030NIA NIH HHS U19 AG032438NICHD NIH HHS R21 HD112910NIDA NIH HHS R01 DA058114NIMH NIH HHS R01 MH128286NIMH NIH HHS R01 MH132962
6 · The paper itself

Abstract

introductionThe hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). We examined the interplay between age and apolipoprotein E (

methodsUsing neuroimaging data from 37,463 UK Biobank participants, we applied linear regression to quantify the association of age and

resultsTotal hippocampal volume declined with age, with significant differences by DISCUSSION: The association of Highlights: Apolipoprotein E (

Indexed as

ageAlzheimer's diseaseapolipoprotein EhippocampusneurodegenerationUK Biobank

Identifiers

PMID39553251
PMCPMC11567847

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.