ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Reply to: Comments on "Functional Outcomes After Trauma in Older Adults With Dementia".Journal of the American Geriatrics Society · 2026Article
- A Longitudinal Analysis of Frontotemporal Dementia Patients in Spain throughout the COVID-19 Pandemic: A Descriptive Study.Dementia and geriatric cognitive disorders · 2026Article
- Examining neuropsychiatric symptoms and functional decline in behavioral variant frontotemporal dementia.International review of psychiatry (Abingdon, England) · 2025Article
- Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Functional Impairment in Behavioral Variant Frontotemporal Dementia: Cognitive, Behavioral, Personality, and Brain Perfusion Contributions.Journal of personalized medicine · 2025Article
- Survival rates in frontotemporal dementia and Alzheimer's disease.Neurodegenerative disease management · 2025Article
- Interpreting Addenbrooke's Cognitive Examination-III Scores in Dementia: Performance Distributions and Clinically Meaningful Change.European journal of neurology · 2025Article
- Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Modeling contributions of cognition and apathy to functional impairment in younger-onset dementia.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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8 authors.
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Abstract
introductionThis study investigated the changes in functional capacity with disease progression in a well-characterised cohort of patients diagnosed with frontotemporal dementia (FTD) and Alzheimer's disease (AD) presentations.
methodsWe recruited 126 behavioural variant FTD (bvFTD), 40 progressive nonfluent aphasia (PNFA), 64 semantic dementia (SD), 45 logopenic progressive aphasia (LPA), and 115 AD patients. Functional capacity was measured annually over ∼7 years using the Disability Assessment for Dementia.
resultsLinear mixed effects models revealed the bvFTD group demonstrated disproportionate functional impairment at baseline and over the study period. Functional capacity among the other syndromes showed a more uniform pattern of decline, with less severe functional impairment at baseline and ∼7%-10% mean annual decline. Baseline correlations indicated different mechanisms supporting basic and complex functional proficiency among the groups. DISCUSSION: Our findings demonstrate distinct functional profiles across dementia syndromes with disease progression. Identifying progression milestones across syndromes will improve clinical management. Highlights: bvFTD shows severe functional impairment at baseline and over time.PNFA, SD, LPA, AD: less severe baseline functional impairment; more uniform decline.General cognition is related to IADLs, but not BADLs, in all groups.Behavioural disturbances relate to IADLs and BADLs in bvFTD and SD.Behavioural-ADL relations are more mixed in PNFA, LPA, and AD.
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