Evidence map›Paper›PMID 39553159›Full record

ReviewCureus2024

Horace Wells: A Pioneer in Modern Anesthesia and Pain-Free Medical Practices.

Laresh N Mistry, Nikita A Khachane, Pakhi P Shah, Mrunmayee Soman, Shreyas Neelkanthan, Ashwin M Jawdekar

Abstract readReview
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laresh N MistryDepartment of Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to Be University) Dental College and Hospital, Navi Mumbai, IND.
Nikita A KhachaneDepartment of Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to Be University) Dental College and Hospital, Navi Mumbai, IND.
Pakhi P ShahDepartment of Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to Be University) Dental College and Hospital, Navi Mumbai, IND.
Mrunmayee SomanDepartment of Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to Be University) Dental College and Hospital, Navi Mumbai, IND.
Shreyas NeelkanthanDepartment of Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to Be University) Dental College and Hospital, Navi Mumbai, IND.
Ashwin M JawdekarDepartment of Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to Be University) Dental College and Hospital, Navi Mumbai, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Horace Wells, a pioneering figure in the field of anesthesia, was born on January 21, 1815, in Hartford, Vermont. He is widely recognized for his groundbreaking discovery of the anesthetic properties of nitrous oxide, a finding that revolutionized pain management in both medical and dental procedures. Wells' contribution marked a pivotal moment in the history of surgery, transforming it from a traumatic, painful ordeal to a more humane and tolerable practice. Wells initially trained as a dentist and began his career in Hartford, USA, where he developed a reputation for his skill and innovation. His interest in finding a solution to the extreme pain patients experienced during dental work led him to experiment with nitrous oxide, also known as "laughing gas." In 1844, after observing its recreational use, Wells hypothesized that nitrous oxide could be used to alleviate pain during surgical procedures. To test his theory, Wells arranged a public demonstration in which he had his own tooth extracted while under the influence of nitrous oxide. The experiment was a success, proving the anesthetic potential of the gas. Although Wells' initial public demonstration in Boston met with skepticism and failure, his work laid the foundation for the development of anesthesiology. Over time, the medical community recognized the significance of his discovery, which opened the door to further advancements in anesthesia, including the use of ether and chloroform. Wells' contributions, particularly to dental surgery and anesthesia, continue to be celebrated. He is remembered as one of the key figures who helped establish the practice of pain-free surgery, changing the course of both medical and dental fields forever. Despite facing early criticism, Wells' discovery of nitrous oxide remains a cornerstone of modern anesthesia.

Indexed as

anesthesiaconscious sedationinhalationnitrous oxidepediatric dentistrytooth extraction

Identifiers

PMID39553159
PMCPMC11566315

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.