Human Immunodeficiency Virus (HIV)/Hepatitis B Virus (HBV) Coinfection and Diffuse Interstitial Lymphocytosis Presenting With Kidney Disease.

Sandeep Sasidharan, Eugene K Yeboah, Surya V Seshan, Thin Thin Soe, Subodh J Saggi

Abstract readCase Reports

In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Sandeep SasidharanNephrology, State University of New York Downstate Health Sciences University, Brooklyn, USA.

Eugene K YeboahInternal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.

Surya V SeshanPathology and Laboratory Medicine, Weill Cornell Medicine, New York, USA.

Thin Thin SoeNephrology, State University of New York Downstate Health Sciences University, Brooklyn, USA.

Subodh J SaggiNephrology, State University of New York Downstate Health Sciences University, Brooklyn, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report highlights a rare presentation of acute kidney injury (AKI) with nephrotic syndrome in a Pacific Islander with concomitant acute HIV and hepatitis B virus (HBV) coinfection, progressing to require hemodialysis; the patient recovered completely and discontinued dialysis after a course of high-dose steroids and initiation of antiviral agents. The renal biopsy revealed features consistent with HIV-associated nephropathy (HIVAN) and HBV-associated nephropathy (HBVAN), along with diffuse interstitial lymphocytosis (DIL) showing dominant CD8 lymphocyte infiltration and high Hep B and HIV viral loads. Management challenges included the decision on the initiation of antiviral agents simultaneously with immunosuppressive agents. DIL syndrome (DILS) has become exceedingly rare since the advent of highly active antiretroviral therapy (HAART). To our knowledge, this is the first reported case of combined nephropathy in HIV-HBV coinfection.

Indexed as

combined nephropathy in hiv-hbv coinfectiondiffuse interstitial lymphocytosis (dil)hbv-associated nephropathy (hbvan)hepatitis b-associated membranoproliferative glomerulonephritis (mpgnhiv associated nephropathy (hivan)

Identifiers

PMID39553156

DOI10.7759/cureus.71765

PMCPMC11569505

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.