ArticleCureus2024
Comparison of Sodium Zirconium Cyclosilicate to Calcium Polystyrene Sulfonate for Acute Hyperkalemia Among Hospitalized Elderly Patients.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Effect of Sodium Zirconium Cyclosilicate Approval on the Management of Acute Hyperkalemia in Japan: Interrupted Time Series Analysis.American journal of nephrology · 2026Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Our aim was to investigate the effect of sodium zirconium cyclosilicate (SZC) on acute hyperkalemia in hospitalized elderly patients. Methods A retrospective observational study was conducted. All consecutive patients aged 65 years or older who were hospitalized in our hospital between January 2020 and September 2023 were screened. Patients with serum potassium greater than 5.0 mEq/L and those who were prescribed either SZC or calcium polystyrene sulfonate (CPS) during hospitalization were included. The primary outcome was the change in serum potassium within 24 hours from baseline. Patients who were prescribed SZC and those who were prescribed CPS were compared by the Mann-Whitney test. Results A total of 87 hospitalized elderly patients with acute hyperkalemia were included. The median age of the patients was 81 years (IQR 75 to 86); 64 (73.6%) were men, and 64 (73.6%) had chronic kidney disease. The median serum potassium concentration was 6.0 mEq/L (IQR 5.7 to 6.4). Of those, 53 patients received SZC, and 35 patients received CPS. While SZC reduced the serum potassium concentration from 6.1 mEq/L to 5.0 mEq/L, CPS reduced the potassium concentration from 5.9 mEq/L to 5.3 mEq/L within 24 hours. Compared with CPS, SZC significantly reduced potassium (
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