Evidence map›Paper›PMID 39553056›Full record

ArticleCureus2024

Comparison of Magnetic Resonance Imaging Features Between Programmed Cell Death 1/Programmed Cell Death Ligand 1 Inhibitor-Induced Hypopituitarism and Idiopathic Hypopituitarism in Japanese Subjects.

Yuichiro Iwamoto, Tomohiko Kimura, Kazunori Dan, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuichiro IwamotoDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Tomohiko KimuraDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Kazunori DanDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Hideyuki IwamotoDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Junpei SanadaDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Yoshiro FushimiDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Yukino KatakuraDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Masashi ShimodaDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Shuhei NakanishiDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Tomoatsu MuneDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Kohei KakuDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Hideaki KanetoDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective Immune checkpoint inhibitor-associated hypopituitarism (ICI-HP) is a rare immune-related adverse event (irAE) of ICIs. This study aimed to identify characteristic pituitary findings on magnetic resonance imaging (MRI) in ICI-HP. Methods This study is a single-center, retrospective, observational study. Among 95 patients admitted to our hospital for examination of hypopituitarism between January 2010 and December 2022, 26 patients with normal pituitary function (NPF), 13 patients with ICI-HP, and 13 patients with idiopathic hypopituitarism (IHP) were included and analyzed. Results For participants with ICI-HP, the time from ICI administration to ICI-HP diagnosis was 125 (56-212) days. Compared to the NPF, participants in the ICI-HP and IHP were significantly older (p<0.01) - the highest number of patients presented with isolated adrenocorticotropic hormone deficiency in both ICI-HP and IHP. Pituitary volume was not significantly different among the three groups (p=0.68). The width of the pituitary stalk was 1.8 (1.5-2.0) mm in NPF and 1.8 (1.7-2.2) mm in IHP, whereas it was 2.4 (2.4-2.7) mm in ICI-HP and was significantly larger compared to the other groups (p<0.01). Conclusion This study identified no pituitary enlargement in ICI-HP compared to NPF or IHP. However, the pituitary stalk was significantly thickened in ICI-HP compared to the other groups. Pituitary stalk enlargement may be a characteristic MRI finding of ICI-HP.

Indexed as

hypopituitarismidiopathic hypopituitarismimmune checkpoint inhibitors (icis)immune-related adverse events (irae)magnetic resonance imaging (mri)

Identifiers

PMID39553056
PMCPMC11568668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.