ArticleCureus2024
Successful Treatment of a Rare Complication of Varicella Pneumonitis in an Immunocompromised 11-Year-Old Child Using Pooled Intravenous Immunoglobulin.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Varicella-zoster virus, or herpes zoster virus, is a human alphaherpesvirus. It causes varicella (chicken pox) and herpes zoster (shingles). Though a relatively common and benign childhood illness, it can lead to severe disseminated infections in immunocompromised patients. Varicella pneumonitis is a common complication of varicella found in adults but is rare in children. As such, we present a rare case of an 11-year-old immunosuppressed male on methotrexate who developed a disseminated varicella infection resulting in pneumonia. Methotrexate is not known to cause immunosuppression, as compared to infliximab, which is similarly indicated for rheumatoid autoimmune conditions. He was treated with high-dose acyclovir and pooled intravenous immunoglobulin (IVIG). Due to the efficacy of high-dose acyclovir in immunocompromised patients with varicella-zoster and modern preparations of IVIG containing high titers of zoster immunoglobulins, the treatment allowed the patient to recover fully.
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