ReviewCureus2024
Critical Analysis of the Effect of Antiresorptive Drugs on Osteonecrosis Associated With Dental Implants: An Umbrella Review.
Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The overview was carried out to evaluate the impact of antiresorptive drug (ARD) therapy in patients undergoing dental implant treatment who significantly experience medication-related osteonecrosis of the jaw (MRONJ) or not. A comprehensive electronic database search within the timeline of 2014-2024, restricted to the English language, was performed in database search engines like Google Scholar, Web of Science, PubMed, and Scopus. The articles were screened using the specific Medical Subject Headings (MeSH) terms and Boolean operators 'OR' and 'AND'. Studies with patients having a history of ARD before, during, or following implant placement were included in the systematic review, without or with meta-analysis. The AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews) tool was utilized to evaluate the quality of the papers. This review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42024583017). There were 10 systematic reviews as per eligibility criteria. The total number of failed implants was 524, out of which the incidence of MRONJ was between the ranges of 2% and 17%. According to the AMSTAR 2 tool, 20% of the studies were rated as medium quality, 60% were rated as low quality, and 20% were rated as critically low quality. Three meta-analyses were observed for the event "MRONJ," and it found no statistically significant differences between dental implant users with ARD and non-ARD participants. The corroborative evidence presents that patients undergoing dental implants with ARD history significantly experience MRONJ if there is a lack of strategic planning of implant placement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.