ArticleJournal of thoracic disease2024
Integrated bioinformatics and machine learning algorithms reveal the unfolded protein response pathways and immune infiltration in acute myocardial infarction.
Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- TSPY-like 2, Beyond the Histone Chaperone Role.Biomolecules · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The unfolded protein response (UPR) is a critical biological process related to a variety of physiological functions and cardiac disease. However, the role of UPR-related genes in acute myocardial infarction (AMI) has not been well characterized. Therefore, this study aims to elucidate the mechanism and role of the UPR in the context of AMI. Methods: Gene expression profiles related to AMI and UPR pathway were downloaded from the Gene Expression Omnibus database and PathCards database, respectively. Differentially expressed genes (DEGs) were identified and then functionally annotated. The random forest (RF) and least absolute shrinkage and selection operator (LASSO) regression analysis were conducted to identify potential diagnostic UPR-AMI biomarkers. Furthermore, the results were validated by using external data sets, and discriminability was measured by the area under the curve (AUC). A nomogram based on the feature genes was developed to predict the AMI-risk rate. Then we utilized two algorithms, CIBERSORT and MCPcounter, to investigate the relationship between the key genes and immune microenvironment. Additionally, we performed uniform clustering of AMI samples based on the expression of UPR pathway-related genes. The weighted gene co-expression network analysis was conducted to identify the key modules in various clusters, enrichment analysis was performed for the genes existing in different modules. Results: A total of 14 DEGs related to the UPR pathway were identified. Among the 14 DEGs, Conclusions: Our study highlights the importance of the UPR pathway in the pathogenesis of myocardial infarction, and identifies four genes
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