Evidence map›Paper›PMID 39552887›Full record

ArticleJournal of thoracic disease2024

The efficacy of neoadjuvant immune checkpoint inhibitors in lung squamous cell carcinoma and adenocarcinoma: a systematic review and single-arm meta-analysis.

Junguo Dong, Qixia Wang, Runchen Wang, Kaiwen Ye, Zhiming Ye, Jiayu Lin, Hengrui Liang, Wei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junguo Dong *Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Qixia Wang *Department of Respiratory, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Runchen Wang *Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Kaiwen YeDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Zhiming YeDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Jiayu LinNanshan School of Medicine, Guangzhou Medical University, Guangzhou, China.
Hengrui LiangDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Wei WangDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neoadjuvant immunotherapy is effective in treating resectable non-small cell lung cancer (NSCLC) but shows different responses in lung squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Current studies are limited in size, necessitating further research to clarify these differences. This study aims to investigate whether there is a difference between the efficacy of neoadjuvant immune checkpoint inhibitors (ICIs) on lung SCC Methods: Studies provided data of pathological or radiological response of ADC and SCC receiving neoadjuvant ICIs published before August 1, 2023, were retrieved. Pathological response included major pathological response (MPR), complete pathological response (cPR) and the sum of major pathological response and complete pathological response (McPR). Radiological response includes complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD), objective response rate (ORR), disease control rate (DCR). The protocol was registered in the Prospective Register of Systematic Reviews (PROSPERO CRD42022328240). Results: A total of 22 studies with 430 patients were included. Pathological response and radiological response were used to evaluate the efficacy of neoadjuvant immunotherapy on ADC and SCC. No significant difference was found in pathological response (MPR: P=0.15; cPR: P=0.61), while SCC had significantly higher ORR (P=0.02), lower SD (P<0.04) and PD (P=0.04) than ADC after neoadjuvant ICIs. Both SCC and ADC achieved significantly higher PR (P<0.01), ORR (P<0.01), and lower SD (P<0.01) when treated with chemo-immunotherapy compared to ICI monotherapy. Chemo-immunotherapy significantly improved the McPR in ADC (P<0.05). Toripalimab showed a higher ORR for both SCC and ADC (P<0.05) without a clear advantage in pathological remission across the ICIs. Pembrolizumab had significantly higher McPR (P<0.05) for treating SCC patients compare to ADC patients. Conclusions: In conclusion, our findings indicate that SCC patients exhibited higher ORR and lower SD and PD than those with ADC. No significant differences in pathological responses were seen between SCC and ADC, across ICI monotherapy or chemo-immunotherapy. Chemo-immunotherapy notably improved McPR in ADC. Toripalimab showed higher ORR in both cancers without distinct pathological remission advantage. Pembrolizumab, however, demonstrated superior McPR in SCC, indicating a preference in treating SCC.

Indexed as

efficacyimmune checkpoint inhibitor (ICI)meta-analysisNeoadjuvant immunotherapynon-small cell lung cancer (NSCLC)

Identifiers

PMID39552887
PMCPMC11565341

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.