ArticleJournal of thoracic disease2024
Efficacy and outcome analysis: monotherapy and combination therapy of S-1 for patients with advanced non-small cell lung cancer.
Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Tolerance and response of afatinib combined with tegafur in patients with advanced biliary tract cancer after failure of gemcitabine-based systemic therapy.Discover oncology · 2026Article
- Real-World Efficacy and Safety of S-1 Monotherapy in Non-Small Cell Lung Cancer Management: Insights From a Multicenter Retrospective Cohort Study.Clinical Medicine Insights. Oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lung cancer is the leading cause of cancer-related mortality worldwide. S-1, a fluorouracil derivative known for its efficacy and minimal adverse effects in various solid tumors, offers hope for advanced non-small cell lung cancer (NSCLC) patients. This study conducted a retrospective, single-center analysis to investigate the effectiveness and safety of S-1 monotherapy and combination therapy as second-line or subsequent treatment for advanced NSCLC. Methods: A total of 52 patients diagnosed with advanced NSCLC at Zhejiang Cancer Hospital (Hangzhou, China) from January 1, 2018, to August 31, 2023 were included in a retrospective study. Among these patients, 13 received S-1 monotherapy while 39 received S-1 in combination therapy. The study aimed to analyze the short-term efficacy, long-term outcome, prognostic factors, and treatment-related adverse events (AEs). Results: The objective response rate (ORR) was 28.8%, with a median progression-free survival (PFS) of 2.7 months [95% confidence interval (CI): 2.1-2.8] and a median overall survival (OS) of 9.5 months (95% CI: 6.3-12.6) for the entire cohort. The combination therapy with S-1 was determined to be a significant independent predictor of OS, while treatment line was identified as an independent negative prognostic factor for OS. The most prevalent AE observed was anemia, affecting 12 patients (23.1%). The majority of AEs were classified as grade 1-2, with only 3 patients (5.7%) experiencing grade 3-4 AEs. Further prospective studies are recommended to fully assess the therapeutic value of this treatment approach. Conclusions: Results indicated that both S-1 monotherapy and combination therapy showed promising efficacy and were well tolerated as second-line or later-line treatments for patients with advanced NSCLC. Further prospective studies are recommended to fully assess the therapeutic value of this treatment approach.
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