Evidence map›Paper›PMID 39552742›Full record

ReviewCureus2024

Innovative Nanotechnological Approaches in Trauma and Orthopaedic Surgery: A Comprehensive Review.

Gaurav Jha, Surya Malasani, Ahmed Barakat, Siri Chandana Sola, Kashish Gera, Garima Gupta

Abstract readReview
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gaurav JhaTrauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Surya MalasaniTrauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Ahmed BarakatTrauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Siri Chandana SolaGeriatrics, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Kashish GeraTrauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Garima GuptaCardiology, University Hospitals of Leicester NHS Trust, Leicester, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of nanotechnology to health has been one of the revolutionizing factors in the field of trauma and orthopaedic surgery over the last decade. Advances in nanomedicine, in comparison to conventional modes of treatment, have influenced immensely the approach towards trauma and orthopaedic surgery and provided some unique answers to some very complex problems like bone reconstruction, soft tissue repair, and prevention of infection. The current narrative review intends to underpin an extensive analysis of modern applications and recent advances in nanotechnology-driven therapies in orthopaedics. Having leveraged unique properties inherent in nanoparticles and nanoscale materials, novel interventions, such as nanostructured scaffolds, drug delivery systems, and bioactive coatings, have flourished into a variety of promising means to enhance osseointegration, accelerate the healing process, and reduce postoperative complications. This review at once acknowledges the huge potential of these technologies and some of the problems impeding their wide-range clinical application, including long-term safety, main regulatory hurdles, and scale-up issues. The following review aims to give orthopaedic surgeons, researchers, and biomedical engineers an overview of the present status and perspectives for the future regarding nanomedicine in trauma and orthopaedic surgery, pointing out the expectations of a much-improved outcome in patients and overall quality of life.

Indexed as

bone regenerationcoated implantsnanomedicineorthopaedic researchorthopaedic surgeryregenerative orthopaedicstargeted drug delivery

Identifiers

PMID39552742
PMCPMC11568882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.