Evidence map›Paper›PMID 39552733›Full record

ArticleCureus2024

Subacute Combined Degeneration of the Spinal Cord Caused by an Impairment in the Functional Vitamin B12 Metabolic Pathway.

Ahmed S Al-Jizani, Snehal Pathak, Punam Palit, Nkechi Achufusi

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ahmed S Al-JizaniGastroenterology, Peterborough City Hospital, Peterborough, GBR.
Snehal PathakInternal Medicine, Peterborough City Hospital, Peterborough, GBR.
Punam PalitMedicine, Peterborough City Hospital, Peterborough, GBR.
Nkechi AchufusiNeurology, Peterborough City Hospital, Peterborough, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subacute combined degeneration (SCD) of the spinal cord is a neurological disorder marked by degeneration in the dorsal and lateral columns, commonly linked to vitamin B12 deficiency. This report presents a case of SCD caused by a functional vitamin B12 deficiency. Although the patient displayed symptoms such as ataxia, sensory deficits, and motor impairment, initial lab tests showed normal serum vitamin B12 levels, complicating the diagnostic process. A comprehensive assessment identified poor nutrition as the root cause affecting the body's vitamin B12 metabolism. This case highlights the importance of considering SCD in patients with neurological symptoms, even when serum B12 levels appear normal. The report calls for greater awareness and thorough evaluation of vitamin B12 metabolic pathways in patients with unexplained neurological symptoms, emphasizing the need for clinicians to look beyond standard serum levels when assessing potential deficiencies.

Indexed as

adult neurologyall neurologyfunctional vitamin b12 deficiencylower limb painsensory ataxiaspinal cord abnormalitiessubacute combined degenerationsubacute combined spinal cord degenerationvitamin b deficiency

Identifiers

PMID39552733
PMCPMC11565457

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.