Evidence map›Paper›PMID 39552606›Full record

ReviewOral diseases2025

Mechanisms Underlying Medication-Related Osteonecrosis of the Jaw.

Kyeongho Lee, Kihun Kim, June Yeon Kim, Jin-Woo Kim, Young-Hoon Kang, Yun Hak Kim, Sung-Jin Kim

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oral diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  6. Dentists' knowledge and practices in supportive care: a French national survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kyeongho LeeDepartment of Oral Histology and Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
Kihun KimDepartment of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Korea.
June Yeon KimDepartment of Oral Histology and Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
Jin-Woo KimDepartment of Oral and Maxillofacial Surgery, Research Institute for Intractable Osteonecrosis of the Jaw, College of Medicine, Ewha Womans University, Seoul, Korea.ORCID https://orcid.org/0000-0002-1672-5730
Young-Hoon KangDepartment of Oral and Maxillofacial Surgery, Changwon Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
Yun Hak KimDepartment of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Korea.ORCID https://orcid.org/0000-0002-9796-8266
Sung-Jin KimDepartment of Oral Histology and Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.

Funding

Basic Science Research Program RS-2023-00223591Medical Research Center program NRF002100131G0002223Ministry of Health & Welfare, Republic of KoreaNational Research Foundation of Korea, and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) HI22C1377
6 · The paper itself

Abstract

objectiveMedication-related osteonecrosis of the jaw (MRONJ) is a rare but debilitating disease characterized by a progressive necrosis of jaw bones in patients who have received anti-resorptive or anti-angiogenic therapies. Unfortunately, we still have no validated preventive or pharmaceutical interventions to help these patients, primarily due to our limited understanding of MRONJ pathogenesis. Here, we offer an extensive review of recent studies relevant to MRONJ pathogenesis. We present a hypothesis regarding the coupling of bone resorption and angiogenesis that relies on osteoblast-derived, matrix-bound vascular endothelial growth factors to explain why ONJ is associated with both anti-resorptive and anti-angiogenic agents.

methodsA narrative review was conducted by searching databases, including PubMed, Scopus, Google Scholar, and Web of Science, to retrieve relevant reports.

resultsReduced bone resorption leads to reduced angiogenesis, and vice versa, creating a vicious cycle that ultimately results in ischemic necrosis of the jaw. Additionally, we suggest that reduced angiogenesis, induced by anti-resorptive or anti-angiogenic agents, aggravates bacterial infection-induced bone necrosis, explaining why the jaw bone is particularly susceptible to necrosis.

conclusionOur novel hypothesis will facilitate the advancement of future research and the development of more targeted approaches to managing MRONJ.

Indexed as

Angiogenesis InhibitorsBisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsJaw DiseasesBone ResorptionHumansNeovascularization, PathologicOsteonecrosisAngiogenesis InhibitorsBone Density Conservation Agents

Identifiers

PMID39552606
PMCPMC12022389

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.