Evidence map›Paper›PMID 39552568›Full record

ArticleMagnetic resonance in medicine2025

Romer-EPTI: Rotating-view motion-robust super-resolution EPTI for SNR-efficient distortion-free in-vivo mesoscale diffusion MRI and microstructure imaging.

Zijing Dong, Timothy G Reese, Hong-Hsi Lee, Susie Y Huang, Jonathan R Polimeni, Lawrence L Wald, Fuyixue Wang

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Combined ADC and TMagnetic resonance in medicine · 2026
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  6. Mapping subarachnoid cerebrospinal fluid circulation in the human brain.bioRxiv : the preprint server for biology · 2026
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  14. Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  15. bioRxiv : the preprint server for biology · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Zijing DongAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0001-9334-0968
Timothy G ReeseAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Hong-Hsi LeeAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0002-3663-6559
Susie Y HuangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Jonathan R PolimeniAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Lawrence L WaldAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Fuyixue WangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0001-8975-2775

Funding

CONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2M
Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2020 to 2026
$10.9M
fMRI Technologies for Imaging at the Limit of Biological Spatiotemporal Resolution: Administrative SupplementR01EB019437 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI POLIMENI, JONATHAN RIZZO, SETSOMPOP, KAWIN · 2015 to 2024
$5.5M
Connectome 2.0: A BRAIN Technology Integration and Dissemination Resource for Ultra-High Gradient Magnetic Resonance Imaging of Human Brain Circuits Across ScalesU24NS137077 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2024 to 2026
$4.0M
Toward a Validated in Vivo Imaging Marker of Axonal Damage Predictive of Progressive Disability in Multiple SclerosisR01NS118187 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2021 to 2025
$2.8M
Advancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging TechnologyU24NS129893 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Fuyixue Wang · 2023 to 2026
$2.6M
Revealing tissue microstructure in the brain gray matter in Alzheimer's disease using in vivo high-gradient diffusion MRIDP5OD031854 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HONG HSI · 2021 to 2025
$2.1M
System Upgrade for Siemens 7T Human MRI SystemS10OD023637 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI WALD, LAWRENCE L · 2017 to 2017
$2.0M
Developing next-generation imaging technologies for in-vivo mesoscale diffusion MRI and microstructure imagingR01EB036507 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Fuyixue Wang · 2025 to 2026
$1.3M
The Control of LPS Heterogeneity and Virulence by C-di-AMP Signaling in P. gingivalisR03DE031854 · NIDCR · UNIVERSITY OF LOUISVILLE · PI MORADALI, FATA · 2022 to 2023
$469k
Developing a validated biomarker of cortical neurodegeneration in Alzheimer's disease using high-gradient diffusion MRIR21AG085795 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2024 to 2025
$459k
Imaging brain-wide subarachnoid and perivascular cerebrospinal fluid flow in aging and Alzheimer's diseaseK99AG083056 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DONG, ZIJING · 2023 to 2024
$268k
NIA NIH HHS K99 AG083056NIA NIH HHS K99AG083056NIA NIH HHS R21 AG085795NIBIB NIH HHS P41 EB030006NIBIB NIH HHS P41EB030006NIBIB NIH HHS R01 EB019437NIBIB NIH HHS R01EB019437NIBIB NIH HHS R01 EB036507NIBIB NIH HHS U01 EB026996NIBIB NIH HHS U01EB026996NIDCR NIH HHS DP5OD031854NIH HHS DP5 OD031854NIH HHS S10 OD023637NIH Office of the Director S10OD023637NINDS NIH HHS R01 NS118187NINDS NIH HHS U24 NS129893NINDS NIH HHS U24NS129893NINDS NIH HHS U24 NS137077
6 · The paper itself

Abstract

purposeTo overcome the major challenges in diffusion MRI (dMRI) acquisition, including limited SNR, distortion/blurring, and susceptibility to motion artifacts. THEORY AND

methodsA novel Romer-EPTI technique is developed to achieve SNR-efficient acquisition while providing distortion-free imaging, minimal spatial blurring, high motion robustness, and simultaneous multi-TE imaging. It introduces a ROtating-view Motion-robust supEr-Resolution technique (Romer) combined with a distortion/blurring-free Echo Planar Time-resolved Imaging (EPTI) readout. Romer enhances SNR through simultaneous multi-thick-slice acquisition with rotating-view encoding, while providing high motion-robustness via a high-fidelity, motion-aware super-resolution reconstruction. Instead of EPI, the in-plane encoding is performed using EPTI readout to prevent geometric distortion, T

resultsUsing Romer-EPTI, we demonstrated distortion-free whole-brain mesoscale in-vivo dMRI at both 3T (500-μm isotropic [iso] resolution) and 7T (485-μm iso resolution) for the first time. Motion experiments demonstrated the technique's motion robustness and its ability to obtain high-resolution diffusion images in the presence of subject motion. Romer-EPTI also demonstrated high SNR gain and robustness in high b-value (b = 5000 s/mm

conclusionThe high SNR efficiency, improved image quality, and motion robustness of Romer-EPTI make it a highly efficient acquisition for high-resolution dMRI and microstructure imaging.

Indexed as

BrainDiffusion Magnetic Resonance ImagingEcho-Planar ImagingImage Processing, Computer-AssistedAlgorithmsArtifactsHumansMotionPhantoms, ImagingSignal-To-Noise Ratiodiffusion imagingEPTIhigh resolutionmesoscalemicrostructuresuper‐resolution

Identifiers

PMID39552568
PMCPMC11782731

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.