Evidence map›Paper›PMID 39552508›Full record

ArticleAnnals of neurology2025

Micro-Doses of DNP Preserve Motor and Muscle Function with a Period of Functional Recovery in Amyotrophic Lateral Sclerosis Mice.

Renjia Zhong, Demi L A Dionela, Nina Haeyeon Kim, Erin N Harris, John G Geisler, Lan Wei-LaPierre

Abstract read
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Article in Annals of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Renjia ZhongDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL.
Demi L A DionelaDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL.
Nina Haeyeon KimDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL.
Erin N HarrisDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL.
John G GeislerMitochon Pharmaceuticals Inc, Blue Bell, PA.
Lan Wei-LaPierreDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL.ORCID 0000-0002-4781-5886

Funding

Using Mitochondrial Ca2+ Uptake as a Therapeutic Target for ALSR01NS127858 · NINDS · UNIVERSITY OF FLORIDA · PI Lan Wei-LaPierre · 2023 to 2026
$2.0M
Using mitochondrial Ca2+ uptake as a therapeutic target for ALSR56NS117429 · NINDS · UNIVERSITY OF FLORIDA · PI WEI-LAPIERRE, LAN · 2021 to 2021
$512k
The impact of mitochondrial Ca2+ uptake in skeletal muscle in ALS pathogenesisR21NS099545 · NINDS · UNIVERSITY OF ROCHESTER · PI WEI-LAPIERRE, LAN · 2018 to 2019
$424k
NINDS NIH HHS NS117429NINDS NIH HHS NS127858NINDS NIH HHS NS99545NINDS NIH HHS R01 NS127858NINDS NIH HHS R21 NS099545NINDS NIH HHS R56 NS117429
6 · The paper itself

Abstract

objectiveMitochondrial dysfunction is one of the earliest pathological events observed in amyotrophic lateral sclerosis (ALS). The aim of this study is to evaluate the therapeutic efficacy of 2,4-dinitrophenol (DNP), a mild mitochondrial uncoupler, in an ALS mouse model to provide preclinical proof-of-concept evidence of using DNP as a potential therapeutic drug for ALS.

methodshSOD1

resultsDNP delayed disease onset; improved motor coordination and muscle performance in vivo; preserved muscle contractile function, neuromuscular junction morphology, and muscle innervation; and reduced inflammation and protein oxidation at 18 weeks old in hSOD1

interpretationOur results strongly support that micro-dose DNP may be used as a potential novel treatment for ALS patients, with a possibility for recovery, when used at optimal doses and time of intervention. ANN NEUROL 2025;97:542-557.

Indexed as

2,4-DinitrophenolAmyotrophic Lateral SclerosisMuscle, SkeletalRecovery of FunctionUncoupling AgentsAnimalsDisease Models, AnimalMaleMiceMice, TransgenicMuscle ContractionNeuromuscular Junction2,4-DinitrophenolUncoupling Agents

Identifiers

PMID39552508
PMCPMC11831883

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.