Evidence map›Paper›PMID 39552351›Full record

ArticleBiomarkers in medicine2024

Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis.

Congde Xu, Nastasia Roth, Carolin Heidel, Ute Hubauer, Stefan Wallner, Ralph Burkhardt, Christine Meindl, Andreas Holzamer, Michael Hilker, Marcus Creutzenberg and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarkers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Congde XuDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Nastasia RothDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Carolin HeidelDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Ute HubauerDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Stefan WallnerDepartment of Clinical Chemistry and Laboratory Medicine, University Medical Center Regensburg, Regensburg, Germany.
Ralph BurkhardtDepartment of Clinical Chemistry and Laboratory Medicine, University Medical Center Regensburg, Regensburg, Germany.
Christine MeindlDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Andreas HolzamerDepartment of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.
Michael HilkerDepartment of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.
Marcus CreutzenbergDepartment of Anesthesiology, University Medical Center Regensburg, Regensburg, Germany.
Samuel SossallaDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Lars MaierDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Kurt DeblDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Carsten JungbauerDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimCardiorenal syndrome (CRS) is common in severe aortic stenosis (AS). Previous studies revealed N-Acetylglucosaminidase (NAG) and Kidney-injury-molecule-1 (KIM-1) as potential markers for CRS. The study aimed to investigate the prognostic capability of NAG, KIM-1, NT-proBNP in severe AS before TAVI. MATERIALS &

methodsPlasma and urine samples were collected from 151 participants before TAVI. Long-term follow-up (median follow-up time 31 months) was conducted to assess all-cause mortality and a composite endpoint of mortality and congestive heart failure.

resultsNT-proBNP was significantly elevated in classical low-flow, low-gradient AS compared to other severe AS phenotypes (

conclusionBaseline NAG and, to a lesser degree, KIM-1 and NT-proBNP provide significant predictive value for all-cause mortality in patients with severe AS before TAVI.

Indexed as

AcetylglucosaminidaseAortic Valve StenosisBiomarkersHepatitis A Virus Cellular Receptor 1Natriuretic Peptide, BrainPeptide FragmentsTranscatheter Aortic Valve ReplacementAgedAged, 80 and overCardio-Renal SyndromeFemaleHumansMalePrognosisSeverity of Illness IndexAcetylglucosaminidaseBiomarkersHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1Natriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)cardiorenal syndromeKIM-1long-term prognosisNAGNT-proBNPTAVITubular biomarkers

Identifiers

PMID39552351
PMCPMC11654809

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.