Evidence map›Paper›PMID 39552330›Full record

ArticleGlobal health action2024

Five lessons from a mid-level health manager intervention to increase uptake of tuberculosis prevention therapy in Uganda: 'it is a completely different thing to implement what you know.'

Jason Johnson-Peretz, Canice Christian, Cecilia Akatukwasa, Fred Atwine, Elijah Kakande, Moses R Kamya, Diane V Havlir, Carol S Camlin, Gabriel Chamie

Abstract read
In one paragraph

Article in Global health action, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jason Johnson-PeretzDepartment of Obstetrics, Gynecology, & Reproductive Sciences, University of California, Oakland, CA, USA.ORCID 0000-0001-9561-6366
Canice ChristianDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Cecilia AkatukwasaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Fred AtwineInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Elijah KakandeInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Moses R KamyaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Diane V HavlirDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Carol S CamlinDepartment of Obstetrics, Gynecology, & Reproductive Sciences, University of California, Oakland, CA, USA.
Gabriel ChamieDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California, San Francisco, CA, USA.

Funding

Simplified Isoniazid Preventive Therapy (SPIRIT) Strategy to Reduce TB BurdenR01AI125000 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 2017 to 2022
$3.9M
Mentorship in patient-oriented research to optimize community-based HIV prevention for adults at high-risk of HIV at alcohol drinking venues in East AfricaK24AA031211 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gabriel Chamie · 2023 to 2026
$785k
NIAAA NIH HHS K24 AA031211NIAID NIH HHS R01 AI125000
6 · The paper itself

Abstract

backgroundLeadership skills are essential for middle-level healthcare manager efficacy. Capacity-building efforts may attempt behavioural change by filling 'knowledge gaps' while neglecting a sustainable application of that knowledge. Sustainable application of that knowledge, or implementation know-how, must resonate with local cultural patterns. When it is neglected, root issues like unclear decision-making space and local authority to interpret policy during implementation remain unaddressed. Particularly in decentralized healthcare systems, the impact can appear in implementation challenges, subjective decision-making, poor teamwork, and an absence of disseminating best practices.

objectivesThe SEARCH-IPT trial led a series of mini-collaborative meetings, which provided business leadership and management training for an intervention group of mid-level healthcare system managers in rural Eastern, East-Central, and Southwestern Uganda to see whether this would increase uptake of isoniazid-prevention therapy (IPT) for people living with HIV (PLHIV) in intervention districts. IPT is known to reduce active tuberculosis (TB), a leading cause of death among PLHIV, by 40-60%.

methodsWe performed a thematic analysis of six focus-group discussions from this intervention (held in May 2019, January 2020, September 2021) and 23 key informant interviews with control group participants (between February and August 2019 and September and December 2020).

resultsAnalysis revealed five implementation skill sets District Health Officers (DHOs) and District Tuberculosis and Leprosy Supervisors (DTLSs) deployed to achieve sustainable implementation and realize their decision-making space. The five practices were as follows: data-based decision-making, root-cause analysis, quality assurance, evidence-based empowerment, and sharing best practices with colleagues.

conclusionThese practices reached beyond outcome measures to address root problems around the DHO's range of authority and elicit buy-in from district health workers. For successful capacity building at the mid-manager level, focusing on core practices as part of competency is objectively implementable and measurable at the system level and does not rely on DHO self-assessments.

Indexed as

HIV InfectionsTuberculosisAntitubercular AgentsCapacity BuildingFemaleHumansIsoniazidLeadershipUgandaAntitubercular AgentsIsoniazidcapacity buildingdecentralizationDecision spacehealthcareHIVimplementationmanagementtuberculosis

Identifiers

PMID39552330
PMCPMC11574955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.