Evidence map›Paper›PMID 39552259›Full record

ArticleInternational journal of cancer2025

Environmental tobacco smoking (ETS) and esophageal cancer: A population-based case-control study in Jiangsu Province, China.

Zi-Yi Jin, Kuangyu Liu, Gina Wallar, Jin-Yi Zhou, Li-Na Mu, Xing Liu, Li-Ming Li, Na He, Ming Wu, Jin-Kou Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zi-Yi JinDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Kuangyu LiuDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.ORCID 0009-0001-6003-3619
Gina WallarDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Jin-Yi ZhouDepartment of non-communicable diseases prevention and control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
Li-Na MuDepartment of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, New York, USA.ORCID 0000-0003-4799-7517
Xing LiuDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.ORCID 0000-0003-1385-9749
Li-Ming LiDepartment of Epidemiology, School of Public Health, Peking University, Beijing, China.
Na HeDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Ming WuDepartment of non-communicable diseases prevention and control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
Jin-Kou ZhaoDepartment of non-communicable diseases prevention and control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
Zuo-Feng ZhangDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.ORCID 0000-0002-4669-3995

Funding

UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERSU01CA096134 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAO, JENNY T · 2002 to 2007
$5.1M
Stem Cell Selection &Expansion Via HOX Gene ActivationR01CA090833 · NCI · UNIVERSITY OF PENNSYLVANIA · PI EMERSON, STEPHEN G · 2001 to 2010
$2.6M
MARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERSR01DA011386 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORGENSTERN, HAL M · 1999 to 2003
$1.8M
Molecular Epidemiology and Gene-Environment InteractionR21ES011667 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 2002 to 2004
$651k
REDUCING INDOOR ALLERGEN EXPOSURES IN NORTHERN MANHATTANR21ES009142 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KINNEY, PATRICK LOTT · 1997 to 2000
$322k
HELICOBACTER PYLORI MALNUTRITION AND GASTRIC CANCERR03CA077954 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1997 to 1998
–
MOLECULAR EPIDEMIOLOGY OF BLADDER CANCERR01ES006718 · NIEHS · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI ZHANG, ZUO-FENG · 1993 to 1995
–
Alper Research Center for Environmental Genomics of the University of California, Los Angeles Jonsson Comprehensive Cancer CenterJiangsu Provincial Health Department RC 2003090National Institutes of Health, National Institute of Environmental Health Sciences, National Cancer Institute, Department of Health and Human Services CA077954National Institutes of Health, National Institute of Environmental Health Sciences, National Cancer Institute, Department of Health and Human Services CA09142National Institutes of Health, National Institute of Environmental Health Sciences, National Cancer Institute, Department of Health and Human Services CA90833National Institutes of Health, National Institute of Environmental Health Sciences, National Cancer Institute, Department of Health and Human Services CA96134National Institutes of Health, National Institute of Environmental Health Sciences, National Cancer Institute, Department of Health and Human Services DA11386National Institutes of Health, National Institute of Environmental Health Sciences, National Cancer Institute, Department of Health and Human Services ES011667National Institutes of Health, National Institute of Environmental Health Sciences, National Cancer Institute, Department of Health and Human Services ES06718NCI NIH HHS R01 CA090833NCI NIH HHS R03 CA077954NCI NIH HHS T32 CA009142NCI NIH HHS U01 CA096134NIDA NIH HHS R01 DA011386NIEHS NIH HHS R21 ES011667
6 · The paper itself

Abstract

Esophageal cancer continues to pose a significant public health issue in areas with increased incidence rates such as China. Although involuntary smoking was defined as a group 1 carcinogen for lung cancer, few studies have explored the impact of environmental tobacco smoking (ETS) on esophageal cancer. In this paper, we examined the association between ETS and esophageal cancer in high-risk groups in Jiangsu Province, China. Epidemiologic data were collected for 2969 newly diagnosed cases and 8019 population controls including exposure to active/passive smoking and risk factors. The unconditional logistic regression model and the semi-Bayes (SB) method were applied to assess adjusted odds ratios (ORs) and confidence intervals (CIs). ETS exposure (ever vs. never) was positively associated with esophageal cancer with an SB-adjusted OR (95% CI) of 1.44 (1.31-1.58) among overall population, and 1.56 (1.35-1.82) among non-smokers (i.e., non-active smokers), with corresponding population attributable fractions of 15.0% (95% CI: 10.3%-18.9%) and 12.1% (95% CI: 8.8%-19.8%), respectively. The association was more prominent in men at work and in women at home, with SB-adjusted OR (95% CI) of 1.36 (1.17-1.58) and 1.61 (1.35-1.58), respectively. A dose-response relationship between ETS exposure and the disease was detected across the entire population as well as in non-smokers. This is the largest population-based case-control study of ETS and esophageal cancer and the first study to evaluate such association among non-smokers in a Chinese population. We recommend strengthening the ongoing anti-tobacco public health initiatives in China with a particular emphasis on creating a tobacco-free work/home environment.

Indexed as

Environmental ExposureEsophageal NeoplasmsTobacco Smoke PollutionAdultAgedCase-Control StudiesChinaFemaleHumansMaleMiddle AgedRisk FactorsTobacco Smoke Pollutioncase–control studyChinaenvironmental tobacco smokingesophageal cancer

Identifiers

PMID39552259
PMCPMC11826109

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.