Evidence map›Paper›PMID 39552192›Full record

ArticleHematological oncology2024

Liposomal Doxorubicin, Vinblastine and Dacarbazine Plus Consolidation Radiotherapy of Residual Nodal Masses for Frontline Treatment in Older Adults With Advanced Stage Classic Hodgkin Lymphoma: Improved Outcome in a Multi-Center Real-Life Study.

M Picardi, A Vincenzi, C Giordano, L De Fazio, N Pugliese, A Scarpa, E Vigliar, G Troncone, D Russo, M Mascolo and 17 more

Abstract readMulticenter Study
In one paragraph

Article in Hematological oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

M PicardiDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
A VincenziDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
C GiordanoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
L De FazioDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
N PuglieseDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
A ScarpaDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
E VigliarDepartment of Public Health, Federico II University Medical School Naples, Naples, Italy.
G TronconeDepartment of Public Health, Federico II University Medical School Naples, Naples, Italy.
D RussoDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
M MascoloDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
G EspositoDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
M PrastaroDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
C SantoroDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
R EspositoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
C G TocchettiDepartments of Translational Medical Sciences, Federico II University Medical School, Naples, Italy.
C MainolfiDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
R FontiDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
S Del VecchioDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
M CarchiaDepartment of Public Health, Federico II University Medical School Naples, Naples, Italy.
C QuaglianoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
A SalemmeDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
V DamianoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
R BiancoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
F TrastulliHematology Unit, Antonio Cardarelli Hospital of National Importance, Naples, Italy.
F RonconiHematology Unit, Antonio Cardarelli Hospital of National Importance, Naples, Italy.
M AnnunziataHematology Unit, Antonio Cardarelli Hospital of National Importance, Naples, Italy.
F PaneDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In elderly patients with high-risk classic Hodgkin lymphoma (c-HL), we evaluated the impact of a new modality treatment without bleomycin, that is, liposomal doxorubicin (NPLD)-based regimen plus consolidation radiotherapy of residual nodal masses (RNMs), on overall survival (OS) and progression free survival (PFS). In this retrospective study (2013-2023) conducted in tertiary hospitals in the bay of Naples (Italy), 50 older adults (median age, 69 years; range, 60-89) with advanced stage c-HL received frontline treatment with MVD ± irradiation. MVD consisted of 25 mg/m

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsDacarbazineDoxorubicinHodgkin DiseaseVinblastineAgedAged, 80 and overChemoradiotherapyFemaleHumansMaleMiddle AgedNeoplasm StagingPolyethylene GlycolsRetrospective StudiesSurvival RateDacarbazineDoxorubicinliposomal doxorubicinPolyethylene GlycolsVinblastinec‐HLconsolidation radiotherapyelderly patientsMVDnon‐pegylated liposomal doxorubicin

Identifiers

PMID39552192
PMCPMC11590052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.