Evidence map›Paper›PMID 39552130›Full record

ArticleXenotransplantation

ECG Features in Orthotopic Cardiac Xenotransplantation: Comparisons With Published Literature.

Chace B Mitchell, Joe Simmons, Sarah J Neal, David C Cleveland, Yaniv Bar-Cohen, John D Cleveland

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Xenotransplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chace B MitchellDivision of Cardiac Surgery, Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, Los Angeles, California, USA.ORCID 0000-0002-1578-726X
Joe SimmonsDepartment of Comparative Medicine, Michale E. Keeling Center for Comparative Medicine, MD Anderson Cancer Center, Bastrop, Texas, USA.ORCID 0000-0003-1815-6831
Sarah J NealDepartment of Comparative Medicine, Michale E. Keeling Center for Comparative Medicine, MD Anderson Cancer Center, Bastrop, Texas, USA.
David C ClevelandDivision of Cardiac Surgery, Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, Los Angeles, California, USA.
Yaniv Bar-CohenDivision of Cardiology, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, Los Angeles, California, USA.
John D ClevelandDivision of Cardiac Surgery, Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, Los Angeles, California, USA.

Funding

Specific Pathogen Free Baboon Research Resource (SPFBRR) - Bridge Funding Administrative SupplementP40OD024628 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WILLIAM D HOPKINS · 2017 to 2026
$15.7M
eGenesis BiotechnologyEledon pharmaceuticalsNHLBI NIH HHS 7R33HL163718-02NIH HHS P40 OD024628NIH HHS P40 OD24628
6 · The paper itself

Abstract

introductionAlthough there is a plethora of literature on electrocardiographic changes following cardiac allotransplantation, there is little in the field of cardiac xenotransplantation. The only published literature to date is that of the first pig-to-human cardiac xenotransplantation. Here we take a close look at the electrocardiographic parameters in four non-human primate recipients of orthotopic cardiac xenotransplantation to develop baseline metrics for comparison.

methodsOrthotopic cardiac xenotransplantion was carried out in four non-human primate recipients. Electrocardiographic parameters were followed at various intervals using an internal hemodynamic monitoring system (DSI) as well as a standard 12-lead electrocardiogram (ECG). ECG intervals were then compared to published literature on porcine ECG intervals and pig-to-human cardiac xenotransplantation.

resultsThere were no significant differences observed between timepoints for HR, PR, QRS, QT, or QTc after cardiac xenotransplantation for each animal subject. ECG parameters were statistically similar to those of in situ mini-pig hearts in the literature. ECG parameters from the DSI on average were shorter than those from a traditional ECG, however, DSI parameters were consistent over time.

conclusionThese results demonstrate the possibility of conduction health for genetically engineered porcine donor hearts following cardiac xenotransplantation. Ongoing work to compare the results of an ECG in a porcine donor heart before and after implantation into a NHP is necessary to better characterize variables that may be at play in the function of the conduction system.

Indexed as

ElectrocardiographyHeart TransplantationTransplantation, HeterologousAnimalsHeterograftsHumansSwineelectrocardiogramxenotransplantation

Identifiers

PMID39552130
PMCPMC13093854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.