Evidence map›Paper›PMID 39552013›Full record

ArticleEnvironmental science & technology2024

Transcriptomic and Methylomic Analyses Show Significant Shifts in Biosynthetic Processes and Reduced Intrapopulation Gene Expression Variance in PAH-Adapted Atlantic Killifish.

Akila Harishchandra, Richard T Di Giulio, Nishad Jayasundara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Akila HarishchandraNicholas School of the Environment, Duke University, Durham 27708, North Carolina, United States.ORCID 0000-0003-1672-4997
Richard T Di GiulioNicholas School of the Environment, Duke University, Durham 27708, North Carolina, United States.
Nishad JayasundaraNicholas School of the Environment, Duke University, Durham 27708, North Carolina, United States.ORCID 0000-0003-2485-6893

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI AMY H HERRING · 2000 to 2026
$56.2M
Duke University Program in Environmental HealthT32ES021432 · NIEHS · DUKE UNIVERSITY · PI Akhenaton-Andrew Dhafir Jones, Joel Newman Meyer · 2013 to 2026
$4.0M
NIEHS NIH HHS P42 ES010356NIEHS NIH HHS T32 ES021432
6 · The paper itself

Abstract

Environmental contaminants pose a significant selection pressure across taxa, potentiating evolved resistance to chemicals. However, rapid evolution may alter molecular and physiological homeostasis leading to trade-offs. To elucidate molecular underpinnings of evolved chemical resistance, we compared liver gene expression and methylation profiles in polycyclic aromatic hydrocarbon (PAH)-adapted Atlantic killifish (

Indexed as

Polycyclic Aromatic HydrocarbonsTranscriptomeAnimalsFundulidaeFundulus heteroclitusWater Pollutants, ChemicalPolycyclic Aromatic HydrocarbonsWater Pollutants, ChemicalAHR pathwayAtlantic killifishElizabeth Riverepigeneticsgene expressionpollutionpolycyclic aromatic hydrocarbonstranscriptomics

Identifiers

PMID39552013
PMCPMC11651382

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.