Evidence map›Paper›PMID 39551895›Full record

Observational studyAnnals of hematology2024

Health-related quality of life and symptom-specific functional impairment among patients treated with parenterally administered complement inhibitors for paroxysmal nocturnal hemoglobinuria.

David Dingli, Avery A Rizio, Lynne Broderick, Kaitlin LaGasse, Sloan Rucker, Michelle K Carty, Elise Burton, Shaquilla Gordon, Glorian P Yen, Jincy Paulose and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Annals of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David DingliMayo Clinic, Rochester, MN, USA.
Avery A RizioQualityMetric, An IQVIA Business, 1301 Atwood Avenue, Suite 216E, Johnston, RI, 02919, USA. arizio@qualitymetric.com.
Lynne BroderickQualityMetric, An IQVIA Business, 1301 Atwood Avenue, Suite 216E, Johnston, RI, 02919, USA.
Kaitlin LaGasseQualityMetric, An IQVIA Business, 1301 Atwood Avenue, Suite 216E, Johnston, RI, 02919, USA.
Sloan RuckerQualityMetric, An IQVIA Business, 1301 Atwood Avenue, Suite 216E, Johnston, RI, 02919, USA.
Michelle K CartyQualityMetric, An IQVIA Business, 1301 Atwood Avenue, Suite 216E, Johnston, RI, 02919, USA.
Elise BurtonJackson Heights, New York, NY, USA.
Shaquilla GordonAltantic Beach, Florida, FL, USA.
Glorian P YenNovartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
Jincy PauloseNovartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
Anumaxine GeevargheseNovartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
Soyon LeeNovartis Pharmaceuticals Corporation, East Hanover, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study describes the health-related quality of life (HRQoL) and symptom-specific functional impairment of patients with paroxysmal nocturnal hemoglobinuria (PNH) in a real-world setting. US-based adults with PNH treated with a parenterally administered complement inhibitor (PACI) for ≥ 6 months completed an online, cross-sectional, observational survey; a subset of patients also participated in semi-structured qualitative interviews. The survey included the PROMIS

Indexed as

Complement Inactivating AgentsHemoglobinuria, ParoxysmalQuality of LifeAdultAgedCross-Sectional StudiesFatigueFemaleHumansMaleMiddle AgedSurveys and QuestionnairesComplement Inactivating AgentsFatigueInterviewPatient-reported outcomesPNHQualitativeSurvey

Identifiers

PMID39551895
PMCPMC11695468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.