ArticleNPJ biofilms and microbiomes2024
Rumen microbiome and fat deposition in sheep: insights from a bidirectional mendelian randomization study.
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Article in NPJ biofilms and microbiomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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21citing papers in PubMed
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21 citing papers in PubMed.
- Effects ofAnimals : an open access journal from MDPI · 2026Article
- The Dietary Inclusion of Corn and Peas Affects the Fecal Bacterial Diversity and Composition of Sarda Goats.Animals : an open access journal from MDPI · 2026Article
- Host-microbial co-regulation mediates rumen volatile fatty acid production and utilization in dairy cows.Science China. Life sciences · 2026Article
- Does a whole millet grain-based diet replace whole corn grain in non-forage diets for goat kids?Tropical animal health and production · 2026Article
- Developmental transition of brown adipose tissue from a thermogenic to a lipogenic phenotype in neonatal goats revealed by single-nucleus transcriptomics.Zoological research · 2026Article
- Age-dependent gut microbiota associated with intramuscular fat deposition in Longdong cashmere goats.Animal microbiome · 2026Article
- Altered rumen bacterial flora is associated with increased lipogenesis of adipose tissue in obese dairy cows before calving.Microbiome · 2026Article
- Effects of Dietary Spirulina Supplementation on Cecal Microbiota, Serum Biochemistry, and Antioxidant Capacity in Lambs.Microorganisms · 2026Article
- Comparative metagenomic analysis of gut microbiomes in Yunnan ponies and Dutch warmblood horses.Frontiers in microbiology · 2026Article
- The hologenome concept and its implications for animal breeding in the multi-omics Era.Genetics and molecular biology · 2026Article
- A guide to network analysis, multi-omics integration, and applications in livestock microbiome research.World journal of microbiology & biotechnology · 2025Review
- Melatonin Enhances Muscle Development and Suppresses Fat Deposition in Cashmere Goats by Implicating Gut Microbiota and Ameliorating Systemic Antioxidant Status.Antioxidants (Basel, Switzerland) · 2025Article
- Host-Adapted Ruminal Microbiota Investigation and Functional Validation of Duolang Sheep-DerivedVeterinary sciences · 2025Article
- The Function of the Lysophospholipase 1 (Animals : an open access journal from MDPI · 2025Article
- Expression of LGALS3 and XPNPEP2 genes and their association with growth traits in sheep.Tropical animal health and production · 2025Article
- Host Genetic Effects and Phenotypic Landscapes of Rumen Bacterial Enterotypes in a Large Sheep Population.Animals : an open access journal from MDPI · 2025Article
- Exploring the cecal microbial community associated with fat deposition in sheep and its possible pathways of action.Microbiology spectrum · 2025Article
- Prevotella stercorea increases fat deposition in Jinhua pigs fed alfalfa grass-based diets.Journal of animal science and biotechnology · 2025Article
- Effects of Grazing in a Low Deciduous Forest on Rumen Microbiota and Volatile Fatty Acid Production in Lambs.Animals : an open access journal from MDPI · 2025Article
- Variation in Intramuscular Fat Deposition of Goats and Sheep and Its Correlation with Gut Microbiota.Foods (Basel, Switzerland) · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Yukun ZhangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Xiaoxue ZhangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, 730046, People's Republic of China.
Chong LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, 730046, People's Republic of China.
Huibin TianState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Xiuxiu WengState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Changchun LinInstitute of Animal Science, Xinjiang Academy of Animal Sciences, Urumqi, 830000, People's Republic of China.
Deyin ZhangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Yuan ZhaoState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Xiaolong LiState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Jiangbo ChengState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Liming ZhaoState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Dan XuState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Xiaobin YangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Zhihua JiangDepartment of Animal Sciences and Center for Reproductive Biology, Washington State University (WSU), Pullman, WA, 99164, USA.
Fadi LiState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China.
Weimin WangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, People's Republic of China. wangweimin@lzu.edu.cn.
Funding
National Natural Science Foundation of China (National Science Foundation of China) 31960653National Natural Science Foundation of China (National Science Foundation of China) 32260818
Abstract
Rumen microbiotas are known to influence the fat deposition (FD) in sheep, but controversy over causality remains unresolved. Here, we performed microbiome-wide association studies (MWAS), microbiome genome-wide association analysis (mbGWAS) and bidirectional mendelian randomization (MR) analyses on 1,150 sheep with genotype data from whole-genome resequencing, 16S rRNA sequencing and multilevel FD-traits data. We quantified the proportion of individual variation in FD-traits explained by host genetics, rumen microbiota, and their interaction effects. We identified 32 rumen microbiota biomarkers including Bifidobacterium that were associated with FD-traits (P
Indexed as
Gastrointestinal MicrobiomeGenome-Wide Association StudyMendelian Randomization AnalysisRNA, Ribosomal, 16SRumenAnimalsBacteriaMicrobiotaSheepRNA, Ribosomal, 16S
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