Evidence map›Paper›PMID 39551735›Full record

Observational studyBMC women's health2024

Menstrual cycle related depressive symptoms and their diurnal fluctuations - an ambulatory assessment study.

Hannah Klusmann, Annette Brose, Lars Schulze, Sinha Engel, Sebastian Laufer, Elise Bücklein, Christine Knaevelsrud, Sarah Schumacher

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC women's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04086316 (Vulnerable and Resilient Phases During the Menstrual Cycle and Their Influence on Depressive Symptoms and Stress. An Ambulatory Assessment Study on Healthy Women and Women With Depression.), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04086316 completednot on this map

Vulnerable and Resilient Phases During the Menstrual Cycle and Their Influence on Depressive Symptoms and Stress. An Ambulatory Assessment Study on Healthy Women and Women With Depression.

TypeobservationalSponsorFreie Universität BerlinRan2020 to 2022Enrolled77ConditionsMajor Depressive Episode
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannah KlusmannDivision of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Schwendenerstraße 27, Berlin, 14195, Germany. h.klusmann@fu-berlin.de.
Annette BroseDivision of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Schwendenerstraße 27, Berlin, 14195, Germany.ORCID http://orcid.org/0000-0001-6774-2189
Lars SchulzeDivision of Clinical Psychology and Psychotherapy, Department of Education and Psychology, Freie Universität Berlin, Habelschwerdter Allee 45, Berlin, 14195, Germany.ORCID http://orcid.org/0000-0003-4720-2411
Sinha EngelDepartment of Experimental Psychopathology, Institute for Psychology, University of Hildesheim, Hildesheim, Germany.ORCID http://orcid.org/0000-0001-9289-7094
Sebastian LauferDivision of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Schwendenerstraße 27, Berlin, 14195, Germany.ORCID http://orcid.org/0000-0002-5184-2801
Elise BückleinDepartment of Psychiatry and Psychotherapy, University Hospital Tübingen, Calwerstr. 14, Tübingen, 72076, Germany.
Christine KnaevelsrudDivision of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Schwendenerstraße 27, Berlin, 14195, Germany.
Sarah SchumacherDivision of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Schwendenerstraße 27, Berlin, 14195, Germany.ORCID http://orcid.org/0000-0002-6955-3493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReproductive mood disorders indicate that within-person variation in depressive symptoms across the menstrual cycle can be related to ovarian hormone changes. Until now, such cycle-related symptom changes have been measured once daily, even though depression research indicates systematic diurnal changes in symptoms. Further, previous research often focused on aggregated depression scores. This study examined whether three daily assessments of depressive symptoms follow similar trajectories across the menstrual cycle and investigated within-person cyclical fluctuation of all individual symptoms and the aggregated score.

methods77 naturally-cycling participants (35 with and 42 without depressive disorder) provided three daily ratings of depressive symptoms across one menstrual cycle to evaluate individual and summarized symptoms.

resultsReliability estimates (w) of the three diurnal measurements ranged from 0.56 to 0.78. Cyclicity showed statistically significant interindividual differences for all symptoms, and individual symptoms differed significantly from each other in their magnitude of cyclicity. LIMITATIONS: Only one menstrual cycle was assessed to reduce participant burden. Further, ovulation testing dates were based on self-reported cycle lengths, and only LH (luteinizing hormone) peaks were tested without subsequent progesterone rises.

conclusionsThe results highlight the need for a symptom-specific approach to assess individual variance in cyclicity of depressive symptoms. Reliability for one daily assessment can be improved by using the afternoon value, a sum score for depressiveness, or multiple items per symptom. Furthermore, this study emphasizes, that depressive symptoms can systematically change across the menstrual cycle, and it is, therefore, important to include it in depression research. Exploring female-specific risk factors of depression will enable the development of person-tailored treatments.

trial registrationThe study was preregistered at ClinicalTrials.gov (NCT04086316) with the first registration on 27/08/2019.

Indexed as

Circadian RhythmDepressionMenstrual CycleAdultFemaleHumansLuteinizing HormoneProgesteroneReproducibility of ResultsYoung AdultLuteinizing HormoneProgesteroneAmbulatory assessmentDepressive disordersDiurnal fluctuationMenstrual cycleMood disordersWomen’s health

Identifiers

PMID39551735
PMCPMC11572536

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.