ArticleAndrology2025
EP300-interacting inhibitor of differentiation 3 is required for spermatogenesis in mice.
Article in Andrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A Follow-Up Study on Testicular Cellular and Transcriptomic Responses to Mild Scrotal Heat Stress in Wugu-Hu and Hu Rams.Animals : an open access journal from MDPI · 2026Article
- EP300-interacting inhibitor of differentiation 3 is required for spermatogenesis in mice.Andrology · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundMammalian spermatogenesis is a highly complex process of cell proliferation, meiosis, and differentiation. A series of genes are expressed in an orderly and precise manner to ensure spermatogenesis, with chromatin undergoing intricate changes throughout. EP300-interacting inhibitor of differentiation 3 (Eid3) is a testis-enriched gene, but its role in male reproduction remains unclear.
objectiveTo investigate the role of EID3 in male spermatogenesis and explore the potential underlying mechanism. MATERIALS AND
methodsWe generated Eid3 knockout mouse model using the CRISPR-Cas9 system. We measured the expression of EID3 in mouse tissues and testicular cell populations by qRT-PCR and western blot. Histological analysis, including hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS) staining, together with computer-assisted sperm analysis (CASA), were performed to evaluate the effect of EID3 on spermatogenesis in mice. Light and ultrastructural microscopy were used to evaluate the morphology and structure of the Eid3
resultsEid3 DISCUSSION AND
conclusionsThis study confirms for the first time that EID3 is crucial for meiosis and chromatin condensation during spermatogenesis, and EID3 deficiency leads to a significant decrease in sperm parameters. Given the high expression paradigm of Eid3 in human testis, EID3 likely plays a role in human reproduction. Future research could provide a new target for the clinical diagnosis and treatment of male infertility.
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