Observational studyThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2025
Practical Assessment of Neuropsychiatric Symptoms: Updated Reliability, Validity, and Cutoffs for the Neuropsychiatric Inventory Questionnaire.
Observational study in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of music therapy on mild cognitive impairment in the aging population: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Effectiveness of Telephone Interventions for the Management of Behavioral and Psychological Symptoms of Dementia in the Community: Systematic Review.Journal of medical Internet research · 2025Pooled it
- The Impact of Augmented Reality-Based Aromatherapy Education on Symptoms in Older Adults with Early-Stage Dementia.Healthcare (Basel, Switzerland) · 2026Article
- Affective neuropsychiatric symptom metrics in the National Alzheimer's Coordinating Center dataset.Journal of Alzheimer's disease : JAD · 2026Article
- Effect of Tai Chi combined with visual-action-sensory rehabilitation therapies on cognitive function in acute ischemic stroke: a study protocol for a randomized controlled trial.Annals of medicine · 2025Article
- Linking traditional and technological activities of daily living: Building modern, adaptable measures of daily functioning.Journal of the International Neuropsychological Society : JINS · 2025Article
- Affective Neuropsychiatric Symptom Metrics in the National Alzheimer's Coordinating Center Dataset.medRxiv : the preprint server for health sciences · 2025Article
- Effects of a Digital, Person-Centered, Photo-Activity Intervention on the Social Interaction of Nursing Home Residents with Dementia, Their Informal Carers and Formal Carers: An Explorative Randomized Controlled Trial.Behavioral sciences (Basel, Switzerland) · 2025Article
- The potential of depressive symptoms to identify cognitive impairment in ageing.European journal of ageing · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesTo improve assessment of neuropsychiatric symptoms (NPS) by expanding the measurement properties of the Neuropsychiatric Inventory Questionnaire (NPI-Q).
designMulticenter, longitudinal observational study.
settingSeveral Alzheimer's Disease Research Centers (ADRCs).
participantsIndividuals (n = 45,274) who presented to an ADRC with a collateral and completed the NPI-Q. MEASUREMENTS: The NPI-Q total severity score, four NPI-Q subscales, dementia stage, expert NPS rating, consensus rating of dementia syndrome, global cognitive screening, collateral rating of daily functioning, and self-rating of depression.
resultsThere was strong evidence of criterion validity with both dementia stage and expert NPS rating for the NPI-Q total severity index, which informed cutoffs and interpretive ranges. Furthermore, subscales had adequate classification of dementia syndromes and appropriate convergent relationships with cognition, daily functioning, and mood. There was good-to-excellent evidence of reliability for the NPI-Q total severity index over several years, and subscales had adequate-to-good reliability.
conclusionsThis is the first study to provide empirically established cutoffs, interpretive ranges, and evidence of reliability over a period longer than a month on the NPI-Q and its subscales. This will improve assessment of NPS in clinical and research contexts. ARTICLE SUMMARY: Neuropsychiatric symptoms of neurodegeneration are increasingly understood as early disease markers with tremendous functional impact later in disease, but are often missed or misdiagnosed. The most common measure of these symptoms, the Neuropsychiatric Inventory Questionnaire (NPI-Q), does not have clinically actionable guidance, which this article provided. We established cutscores for several conditions and test-retest reliability over longer periods for the total score and subscales using a multicenter database.
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