Evidence map›Paper›PMID 39551620›Full record

ArticleThe European journal of neuroscience2024

Behavioural phenotypes of Dicer knockout in the mouse SCN.

Ngoc-Hien Du, Konstantinos Kompotis, Miho Sato, Erica Pedron, Sabrina Androvic, Steven Brown

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European journal of neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Behavioural phenotypes of Dicer knockout in the mouse SCN.The European journal of neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ngoc-Hien DuInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0009-0007-3525-8094
Konstantinos KompotisInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Miho SatoInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Erica PedronInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Sabrina AndrovicInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Steven BrownInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The suprachiasmatic nucleus (SCN) is the master clock that directly dictates behavioural rhythms to anticipate the earth's light/dark cycles. Although post-transcriptional regulators called microRNAs have been implicated in physiological SCN function, how the absence of the entire mature miRNome impacts SCN output has not yet been explored. To study the behavioural consequences of miRNA depletion in the SCN, we first generated a mouse model in which Dicer is inactivated in the SCN by crossing Syt10

Indexed as

Circadian RhythmMice, KnockoutMicroRNAsPhenotypeRibonuclease IIISuprachiasmatic NucleusAnimalsBehavior, AnimalDEAD-box RNA HelicasesMaleMiceMice, Inbred C57BLMotor ActivityDEAD-box RNA HelicasesDicer1 protein, mouseMicroRNAsRibonuclease IIIcircadian rhythmsDicer knockoutlocomotor activitymiRNAsperiod lengthSCN

Identifiers

PMID39551620
PMCPMC11612849

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.