Evidence map›Paper›PMID 39551494›Full record

ArticleThe Journal of veterinary medical science2025

A clinical case of CACNA1S-related muscle weakness in a Holstein calf with congenital astasia diagnosed by a genotyping test of stored blood.

Hisashi Inokuma, Masaki Maezawa, Yoshiyuki Miyazaki, Atsushi Ogino, Ken-Ichi Watanabe, Yoshiyasu Kobayashi

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hisashi InokumaDepartment of Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
Masaki MaezawaDepartment of Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
Yoshiyuki MiyazakiMaebashi Institute of Animal Science, Livestock Improvement Association of Japan, Gunma, Japan.
Atsushi OginoMaebashi Institute of Animal Science, Livestock Improvement Association of Japan, Gunma, Japan.
Ken-Ichi WatanabeDepartment of Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
Yoshiyasu KobayashiDepartment of Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A homozygous calf with CACNA1S-related muscle weakness, a new autosomal recessive congenital disorder in Holstein cattle, was identified by genotyping 195 stored blood samples from Holstein calves aged less than 12 months. The patient was an 8-day-old male calf with congenital astasia which presented to a university hospital in 2019. The patient was unable to maintain an upright position with assistance to stand. Congenital abnormalities in the central nervous system were suspected, but necropsy revealed no specific lesion, with no clear diagnosis. CACNA1S-related muscle weakness should be considered a cause of congenital astasia or weakness in calves. Genotyping is required for a definitive diagnosis because clinical and laboratory findings are non-specific.

Indexed as

Cattle DiseasesMuscle WeaknessAnimalsAtaxiaCalcium Channels, L-TypeCattleGenotypeMaleCalcium Channels, L-Typeearly onset muscle weakness syndromeHolsteinrecessive genetic disorder

Identifiers

PMID39551494
PMCPMC11735212

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.