Evidence map›Paper›PMID 39551462›Full record

ReviewExperimental neurology2025

Protein arginine methyltransferases as regulators of cellular stress.

Julia Zaccarelli-Magalhães, Cristiane Teresinha Citadin, Julia Langman, Drew James Smith, Luiz Henrique Matuguma, Hung Wen Lin, Mariana Sayuri Berto Udo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia Zaccarelli-MagalhãesDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Cristiane Teresinha CitadinDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Julia LangmanDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Drew James SmithDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Luiz Henrique MatugumaDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Hung Wen LinDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA. Electronic address: kevin.lin.1@uth.tmc.edu.
Mariana Sayuri Berto UdoDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA. Electronic address: Mariana.S.BertoUdo@uth.tmc.edu.

Funding

Using Photobiomodulation to Alleviate Brain Hypoperfusion in Alzheimer's DiseaseR01AG081874 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Hung Wen (Kevin) Lin, Quanguang Zhang · 2023 to 2026
$2.5M
Protein Arginine Methyltransferases in Alzheimer's diseaseR01AG081258 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Hung Wen (Kevin) Lin · 2024 to 2026
$2.3M
Protein arginine methyltransferase-mediated vascular dementia in sickle cell diseaseRF1NS132291 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIN, HUNG WEN (KEVIN) · 2023 to 2023
$2.2M
American Heart Association-American Stroke Association 970253NIA NIH HHS R01 AG081258NIA NIH HHS R01 AG081874NINDS NIH HHS RF1 NS132291
6 · The paper itself

Abstract

Arginine modification can be a "switch" to regulate DNA transcription and a post-translational modification via methylation of a variety of cellular targets involved in signal transduction, gene transcription, DNA repair, and mRNA alterations. This consequently can turn downstream biological effectors "on" and "off". Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs 1-9) in both the nucleus and cytoplasm, and is thought to be involved in many disease processes. However, PRMTs have not been well-documented in the brain and their function as it relates to metabolism, circulation, functional learning and memory are understudied. In this review, we provide a comprehensive overview of PRMTs relevant to cellular stress, and future directions into PRMTs as therapeutic regulators in brain pathologies.

Indexed as

Protein-Arginine N-MethyltransferasesAnimalsArginineBrainHumansMethylationStress, PhysiologicalArginineProtein-Arginine N-MethyltransferasesBrain injuryCellular stressNeuroinflammationProtein arginine methyltransferasesTranscription factors

Identifiers

PMID39551462
PMCPMC11973959

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.