ArticleThe Journal of nutrition2025
Metabolic Mechanisms Underlying the Association Between the Profertility Diet and In Vitro Fertilization End Points.
Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bile Acid Metabolism Regulates Ovarian Function: Networks and Reproductive Health Applications.Expert reviews in molecular medicine · 2026Review
- Vitamin B6 promotes the activation of primordial follicles through the PI3K/Akt signaling pathway.Journal of ovarian research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundThe profertility diet is a dietary pattern composed of nutrients and foods most consistently associated with in vitro fertilization (IVF) end points in women.
objectivesWe examined the potential biological mechanisms underlying the association between adherence to a profertility diet and IVF end points using high-resolution metabolomics.
methodsAmong 120 women who underwent an autologous oocyte IVF cycle (2007-2015) in Northeast United States, we collected a serum sample during controlled ovarian stimulation and a follicular fluid sample on the day of oocyte retrieval. Women completed a food frequency questionnaire upon enrollment into the study to examine adherence to the profertility diet pattern. Liquid chromatography with high-resolution mass spectrometry was used for untargeted metabolomic analysis of biospecimens. We identified metabolic features (and enriched biological pathways) associated with the profertility diet and 2 IVF end points, live birth and clinical pregnancy, via a meet-in-the-middle approach.
resultsIn the follicular fluid metabolome, vitamin D-3 metabolism was associated with adherence to the profertility diet pattern and live birth. Additionally, vitamin D-3 metabolism, vitamin B-6 metabolism, and bile acid biosynthesis were associated with both adherence to the profertility diet pattern and clinical pregnancy. In the serum metabolome, only tryptophan metabolism was associated with adherence to the profertility diet pattern and live birth. We confirmed the chemical identity of a metabolite with level 1 evidence, 4-pyridoxate, which was higher in the serum and follicular fluid among women with stronger adherence to the profertility diet pattern and among women with a live birth.
conclusionsThe beneficial association between adherence to the profertility diet and IVF outcomes may be mediated through vitamin D-3 metabolism, vitamin B-6 metabolism, and bile acid biosynthesis in the follicular fluid and tryptophan metabolism in the serum. These results provide new insight in the important biological pathways underlying a dietary pattern providing optimal fertility benefits to women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.