Evidence map›Paper›PMID 39550987›Full record

ArticleAutonomic neuroscience : basic & clinical2024

Intrinsic versus extrinsic contribution to intraindividual sweat rate variability of individual eccrine glands.

Emily K Woolf, Nicole Wells, Jeff Moore, Sarah Northway, Michael J Buono

Abstract read
In one paragraph

Article in Autonomic neuroscience : basic & clinical, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily K WoolfSchool of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America; Reproductive Endocrinology and Women's Health Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States of America.
Nicole WellsSchool of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America.
Jeff MooreSchool of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America; The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, CA 90502, United States of America. Electronic address: jmoore714@gmail.com.
Sarah NorthwaySchool of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America.
Michael J BuonoSchool of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America; Department of Biology, San Diego State University, San Diego, CA 92182, United States of America.

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leanne Maree Redman · 2005 to 2026
$26.5M
Training in Obesity ResearchT32DK064584 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CORBY K MARTIN, Christopher D Morrison · 2003 to 2026
$5.3M
Examining dietary and metabolomics patterns on cardiometabolic outcome variability in response to calorie restrictionF32HL176217 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI WOOLF, EMILY KATLYN · 2024 to 2025
$158k
NHLBI NIH HHS F32 HL176217NIDDK NIH HHS P30 DK072476NIDDK NIH HHS T32 DK064584
6 · The paper itself

Abstract

The purpose of the current study was twofold. First, to determine the intraindividual variability of sweat rate per gland for a given skin location during exercise in the heat. Second, to determine the relative importance of intrinsic vs. extrinsic factors as the source of the intraindividual variability in the sweat rate per gland. Sweat rate of individual eccrine glands on the forearm was measured following pilocarpine iontophoresis and during exercise in the heat. In five participants during exercise in the heat, the measured sweat rate for individual forearm eccrine glands (n = 500) ranged from 0.5 nL/gland/min to 16 nL/gland/min, or over a 30-fold difference. The mean (SD) intraindividual coefficient of variation in sweat rate per gland was 36 (5)% and 49 (10)% (p = 0.008) following pilocarpine iontophoresis and during exercise in the heat, respectively. Such results suggest that intrinsic factors (i.e., sweat gland size and cholinergic sensitivity) contribute approximately three times more than extrinsic factors (i.e., sweat gland nerve fiber density and threshold amplitude) towards explaining the large intra-person variability in sweat rate per gland seen during exercise in the heat.

Indexed as

Eccrine GlandsIontophoresisPilocarpineSweatingAdultExerciseFemaleForearmHot TemperatureHumansMaleMuscarinic AgonistsYoung AdultMuscarinic AgonistsPilocarpineEccrine sweat glandExerciseSweat rateSweat rate variability

Identifiers

PMID39550987
PMCPMC12036337

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.